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Metabolic syndrome in normoglycaemic elderly men

Authors

  • W.-C. Lian,

    1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital and School of Medicine, Tzu Chi University, Hualian, Taiwan
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  • J.-D. Lin,

    1. Division of Endocrinology and Metabolism, Department of Medicine, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan
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  • T.-L. Hsia,

    1. Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
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  • C.-H. Hsu,

    1. Department of Family Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
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  • C.-Z. Wu,

    1. Division of Endocrinology and Metabolism, Department of Medicine, Shuang-Ho Hospital, Taipei Medical University, Taipei, Taiwan
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  • C.-H. Hsieh,

    1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan
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  • D. Pei,

    1. Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
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  • Y.-L. Chen

    Corresponding author
    1. Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
    • Division of Endocrinology and Metabolism, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital and School of Medicine, Tzu Chi University, Hualian, Taiwan
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  • Disclosures

    All the authors have no conflict of interest in this study.

Correspondence to:

Yen-Lin Chen

Department of Pathology

Cardinal Tien Hospital, No. 362

Chung-Cheng Road

Xindian, New Taipei City 23137, Taiwan

Tel.: +886 2 22193391

Fax: +886 2 22191361

Email: anthonychen0719@msn.com

Summary

Objective

Type-2 diabetes is mainly the metabolic defect involving multiple organs. To conclude their intricate relationships, the term ‘ominous octet’ had been proposed to denote this phenomenon. In this study, we enrolled older men without any medications for MetS components to further elucidate the relationships between normoglycaemic state and MetS.

Methods

We enrolled male subjects with FPG less than 100 mg/dl and aged 65 and older undergoing routine health check-ups in Taiwan. After excluding subjects taking medications that might affect the components of MetS, a total of 6679 men were eligible for the analysis. Study subjects were further grouped into FPG tertiles (< 91 mg/dl, 92–95 mg/dl and > 95 mg/dl for tertil 1, tertil 2 and tertil 3, respectively).

Results

There was a significant trend between the FPG and percentages of subjects having MetS (p = 0.009). The relationships between the MetS components were higher in FPG 2 and FPG 3 than FPG 1. In simple correlation, all of the MetS and LDL-C were positively correlated with FPG level and multiple regression further confirmed the same result except for HDL-C that became non-significant. Subjects in FPG3 had significantly higher ORs (ORs = 1.19) for having MetS than those in FPG1.

Conclusions

In conclusion, higher FPG still had higher risk of having MetS in normoglycaemic range in elderly male. More strict FPG level control may be valuable in CVD prevention and warrants further investigations.

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