Early combination therapy with telmisartan plus amlodipine for rapid achievement of blood pressure goals
Article first published online: 16 AUG 2013
© 2013 John Wiley & Sons Ltd
International Journal of Clinical Practice
Volume 67, Issue 9, pages 843–852, September 2013
How to Cite
Neldam, S., Dahlöf, B., Oigman, W. and Schumacher, H. (2013), Early combination therapy with telmisartan plus amlodipine for rapid achievement of blood pressure goals. International Journal of Clinical Practice, 67: 843–852. doi: 10.1111/ijcp.12180
H. Schumacher is an employee of Boehringer Ingelheim. S. Neldam, B. Dahlöf and W. Oigman have no conflicts of interest.
Linked Comment: Wierzbicki and Ferro. Int J Clin Pract 2013; 67: 822–4.
- Issue published online: 16 AUG 2013
- Article first published online: 16 AUG 2013
- Manuscript Accepted: 1 APR 2013
- Manuscript Received: 11 JAN 2013
Rapid and sustained blood pressure (BP) goal attainment is important to reduce cardiovascular risk. Initial use of combination therapy may improve BP goal attainment.
The Boehringer Ingelheim trial database was searched for randomised, double-blind studies comparing telmisartan/amlodipine combination therapy with monotherapy. Eight studies were identified. Eight separate analyses were used to compare combination therapy with respective monotherapies at the earliest available time points (weeks 1, 2 and/or 4).
In patients initiated on combination therapy, greater systolic BP (SBP)/diastolic BP (DBP) reductions were seen with combination therapy (p < 0.0001); BP (< 140/90 mmHg), SBP (< 140 mmHg) and DBP (< 90 mmHg) goal attainment rates were significantly higher with combination therapy at all time points. In patients uncontrolled by monotherapy, greater SBP/DBP reductions were seen with combination therapy (p < 0.05 in all but one measure), and all goal attainment rates were significantly higher with combination therapy, except in one measure.
Many people can achieve their BP targets when taking a combination of telmisartan and amlodipine after failing to do so with monotherapy. Furthermore, BP targets can be achieved more rapidly using a combination of telmisartan and amlodipine as initial therapy than with either monotherapy.