Dr Leggio's current affiliations are: Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (NIH), Bethesda, MD; and Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA.
Article first published online: 8 JUL 2013
© 2013 John Wiley & Sons Ltd
International Journal of Clinical Practice
Volume 67, Issue 9, pages 918–921, September 2013
How to Cite
Mirijello, A., Addolorato, G., D'Angelo, C., Ferrulli, A., Vassallo, G., Antonelli, M., Leggio, L. and Landolfi, R. (2013), Baclofen in the treatment of persistent hiccup: a case series. International Journal of Clinical Practice, 67: 918–921. doi: 10.1111/ijcp.12184
- Issue published online: 16 AUG 2013
- Article first published online: 8 JUL 2013
- Manuscript Accepted: 5 APR 2013
- Manuscript Received: 4 OCT 2012
Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.
To test baclofen administration for the treatment of persistent hiccup.
We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.
Hiccup stopped in all patients after a single administration of the drug.
Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.