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Summary

Background

Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.

Aim

To test baclofen administration for the treatment of persistent hiccup.

Method

We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.

Results

Hiccup stopped in all patients after a single administration of the drug.

Conclusions

Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.