Article first published online: 22 DEC 2013
© 2013 John Wiley & Sons Ltd
International Journal of Clinical Practice
Volume 68, Issue 2, pages 262–270, February 2014
How to Cite
Xiao, M., Gao, Y. and Wang, Y. (2014), Helicobacter species infection may be associated with cholangiocarcinoma: a meta-analysis. International Journal of Clinical Practice, 68: 262–270. doi: 10.1111/ijcp.12264
There are no conflicts of interest.
- Issue published online: 26 JAN 2014
- Article first published online: 22 DEC 2013
- Manuscript Accepted: 18 JUL 2013
- Manuscript Received: 3 MAY 2013
- National Natural Science Foundation of China. Grant Number: 31100701
- Ministry of Education of China. Grant Number: 20114433120001
- Southern Medical University Zhujiang Hospital Young Talent Project. Grant Number: 2012003
Since the discovery of Helicobacter species in human biliary system, the association between Helicobacter species infection and cholangiocarcinoma is under debate. This meta-analysis aims to explore this issue.
Literature search was carried out to identify all eligible articles. We performed overall meta-analysis of all included studies and subgroup analysis based on regional distribution. Subgroup analysis in the light of detection methods and specimens was also conducted.
Ten case–control studies were included. Overall meta-analysis favoured a significant association between Helicobacter species infection and cholangiocarcinoma (cumulative OR 8.88, 95% CI 3.67–21.49). Subgroup analysis based on geographic distribution indicated that Helicobacter species infection may serve as a risk factor not only in a region with high cholangiocarcinoma incidence (Asia, OR 6.68, 95% CI 2.29–19.49) but also in low incidence region (Europe, OR 14.90, 95% CI 4.79–46.35). The other subgroup analysis showed that PCR was the most effective and efficient method to detect Helicobacter species in surgically resected tissue and bile. There was significant heterogeneity among studies and obvious publication bias.
Our meta-analysis supports the possible association between Helicobacter species infection and cholangiocarcinoma. Further investigations are required to clarify the role of Helicobacter species in this malignancy.