Get access

Ethosomes in hair dye products as carriers of the major compounds of black tea extracts

Authors


  • Funding sources: The work was supported in part by the Animal Technology Institute, Miaoli, Taiwan.
  • Conflicts of interest: None.

Correspondence

Feng-Lin Hsu, PhD

Graduate Institute of Pharmacognosy

Taipei Medical University

250 Wusing Street, Taipei 110, Taiwan

E-mail: hsu0320@tmu.edu.tw

Abstract

Objectives

This study describes a novel carrier, the ethosome-based system, which is composed of non-ionic surfactants, ethanol, and water.

Methods

Brij®52 (non-ionic surfactants), soya phosphatidylcholine (PC), cholesterol, and the major compounds (caffeine and gallic acid) of black tea extracts were dissolved in the ethanolic phase. The aqueous phase containing Paragon III was heated to 60 °C and mixed with the previous solution. Finally, 3.4 ml NaOH (6.5 N) was added to adjust the pH level to 4.05. The mixture was centrifuged at 2000 g for two minutes, and the precipitate was taken as the end product. Black tea extracts were applied in ethosome-based formulations, and the efficacy of these formulations in penetrating nude mouse skin and in dyeing white hairs was investigated.

Results

Compared with an ethanolic solution and black tea extracts, the non-ionic ethosomal delivery system dramatically enhanced the adsorption of black tea extracts onto hair surfaces in vitro. The non-ionic ethosomal system was much more efficient in delivering and facilitating the adsorption of black tea extracts to the hair surface than hydroalcoholic black tea extracts.

Conclusions

This formulation may have potential for development as a hair dye and protective agent.

Get access to the full text of this article

Ancillary