Conflicts of interest: None.
Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy
Article first published online: 20 JUN 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 10, pages e443–e448, October 2014
How to Cite
Mirmirani, P., Maurer, T., Cohen, M., D'Souza, G., Karim, R., Plankey, M., Robison, E., Sharma, A., Tien, P. C. and Hessol, N. A. (2014), Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. International Journal of Dermatology, 53: e443–e448. doi: 10.1111/ijd.12044
- Issue published online: 15 SEP 2014
- Article first published online: 20 JUN 2013
- National Institute of Allergy and Infectious Diseases. Grant Numbers: UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590
- Eunice Kennedy Shriver National Institute of Child Health and Human Development. Grant Number: UO1-HD-32632
- National Cancer Institute
- National Institute on Drug Abuse
- National Institute on Deafness
- Other Communication Disorders
- National Center for Research Resources. Grant Number: UL1 RR024131
Normal lipid metabolism and functioning of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study.
Hair characteristics and scalp inflammation were assessed by an interviewer-administered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors.
There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4–3.8).
Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.