Conflict of interest: None
Role of NF-κB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens
Article first published online: 28 APR 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 5, pages 570–574, May 2014
How to Cite
Moorchung, N., Kulaar, J. S., Chatterjee, M., Vasudevan, B., Tripathi, T. and Dutta, V. (2014), Role of NF-κB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens. International Journal of Dermatology, 53: 570–574. doi: 10.1111/ijd.12050
- Issue published online: 23 APR 2014
- Article first published online: 28 APR 2013
NF-κB is a transcription factor belonging to the Re1 family, and it regulates the activity of a large number of proinflammatory genes. Its role in psoriasis, which is a prototype chronic inflammatory disease, is therefore expected to be considerable. It has been found that many of the triggering factors for psoriasis initiate inflammation by activation of NF-κB.
Skin biopsies of 74 psoriatic cases were studied for the grade of NF-κB staining. They were then correlated with the histopathological indices of severity, especially epidermal hyperplasia and inflammatory infiltrate.
Epidermal nuclear positivity for NF-κB correlated with the grade of epidermal hyperplasia (P = 0.043). There was a significant correlation between grade of basal cell positivity of NF-κB and inflammatory infiltrate (P = 0.004). Lymphocyte staining showed a strong correlation with epidermal and basal cell staining pattern for NF-κB (P = 0.004 and 0.003, respectively). There was, however, no correlation of lymphocyte staining with any histopathological parameter. There was also a peculiar propensity for NF-κB to show a positive nuclear stain at the tips of dermal papillae.
The study has demonstrated that translocation of NF-κB in the epidermis and basal cells is responsible for two of the key pathological features of psoriasis, epidermal hyperplasia, and inflammation. We have postulated that translocation of NF-κB in lymphocytes, in psoriatic skin leads to NF-κB translocation in the epidermis and basal cells. NF-κB is therefore likely to be one of the key molecules in the pathogenesis of psoriasis.