Young Bok Lee and Hee Jung Kim are co-first authors.
Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors
Article first published online: 29 OCT 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 6, pages 723–730, June 2014
How to Cite
Lee, Y. B., Kim, H. J., Jung, H. Y., Park, Y. G., Kim, S. Y., Cho, B. K., Cho, D. and Park, H. J. (2014), Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors. International Journal of Dermatology, 53: 723–730. doi: 10.1111/ijd.12057
Daeho Cho and Hyun Jeong Park are co-corresponding Authors
Conflicts of interest: None.
- Issue published online: 19 MAY 2014
- Article first published online: 29 OCT 2013
- National Research Foundation of Korea
- Ministry of Education, Science and Technology. Grant Number: 2012046972
Erythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors.
To investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant™ software.
Erythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma.
The expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.