Conflicts of interest: None.
Assessment of the serum paraoxonase activity and oxidant/antioxidant status in patients with recurrent aphthous stomatitis
Article first published online: 8 JUL 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 52, Issue 10, pages 1259–1264, October 2013
How to Cite
Bilgili, S. G., Ozkol, H., Takci, Z., Ozkol, H. U., Karadag, A. S. and Aslan, M. (2013), Assessment of the serum paraoxonase activity and oxidant/antioxidant status in patients with recurrent aphthous stomatitis. International Journal of Dermatology, 52: 1259–1264. doi: 10.1111/ijd.12084
- Issue published online: 23 SEP 2013
- Article first published online: 8 JUL 2013
Several studies have indicated that recurrent aphthous stomatitis (RAS) is associated with oxidative stress. The aim of this study was to investigate serum paraoxonase (PON) activity and oxidant/antioxidant status in patients with RAS.
Design and methods
Thirty-one patients with RAS and 31 healthy controls were enrolled. Serum PON1 and arylesterase activities, total antioxidant capacity, total oxidant status, and oxidative stress index were determined.
Serum total antioxidant capacity levels, PON1, and arylesterase activities were significantly lower in RAS than controls (P < 0.001), while total oxidant status levels and oxidative stress index were significantly higher (P < 0.001). PON1 activity had a significant correlation with high-density lipoprotein cholesterol only (r = 0.482, P < 0.05), while there were no correlations with other lipids (P > 0.05) in patients with RAS.
Our results indicate that RAS is associated with decreased PON1 activity and increased oxidative stress that plays a crucial role in the pathogenesis of RAS. Further studies on a larger number of patients are needed to verify these results.