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Clinical and laboratory features of chronic idiopathic urticaria in the elderly

Authors

  • Eli Magen MD,

    Corresponding author
    1. Leumit Health Services, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
    2. Medicine B Department, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
    3. Allergy and Clinical Immunology Unit, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
    • Correspondence

      Dr. Eli Magen, md

      Medicine B Department

      Barzilai Medical Center

      Ben Gurion University of Negev

      Barzilai Hospital

      Ashkelon

      Israel

      E-mail: allergologycom@gmail.com

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  • Joseph Mishal MD,

    1. Medicine B Department, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
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  • Menachem Schlesinger MD

    1. Allergy and Clinical Immunology Unit, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
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  • Funding: None.
  • Conflicts of interest: None.

Abstract

Background

There are few data regarding epidemiology and clinical features of urticarial diseases in the elderly population.

Objective

The aim of the study was to determine the clinical and laboratory characteristics of chronic idiopathic urticaria (CIU) in the geriatric population.

Methods

Electronic medical records of outpatient allergy consultations due to a diagnosis of CIU were retrospectively reviewed to collect demographic data, urticaria activity score, results of autologous serum skin test (ASST), and laboratory workup.

Results

From 1598 patients with chronic urticaria, there were 1319 (82.5%) adult (adult CIU group) and 124 (9.4%) elderly subjects (elderly CIU group). The elderly CIU group was characterized by lower prevalence (46.7%) of women compared to the adult CIU group (69.2%; P = 0.022); fewer wheals (1.4 ± 0.5) vs. (2.3 ± 0.7; P < 0.001); lower rates of concomitant symptomatic dermographism 2 (2.2%) vs. 121 (12.6%; P = 0.003); and lower rates of angioedema, 3 (14.1%) vs. 362 (37.8%; P < 0.001). Fewer elderly patients with CIU (18.1%) than adult patients with CIU (44.7%; P = 0.019) demonstrated a positive ASST. There were no differences in laboratory data between the study groups.

Conclusion

CIU in the elderly population is nearly equally distributed in both sexes and is characterized by fewer wheals, lower rates of concomitant symptomatic dermographism, lower rates of angioedema, and lower ASST positivity.

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