Conflict of interest: Kevin P.C. Minbiole and Reid N. Harris have filed a patent application in relation to this work.
The cutaneous bacterium Janthinobacterium lividum inhibits the growth of Trichophyton rubrum in vitro
Version of Record online: 22 AUG 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 54, Issue 2, pages 156–159, February 2015
How to Cite
Ramsey, J. P., Mercurio, A., Holland, J. A., Harris, R. N. and Minbiole, K. P. C. (2015), The cutaneous bacterium Janthinobacterium lividum inhibits the growth of Trichophyton rubrum in vitro. International Journal of Dermatology, 54: 156–159. doi: 10.1111/ijd.12217
- Issue online: 23 JAN 2015
- Version of Record online: 22 AUG 2013
- National Science Foundation. Grant Numbers: 0640373, 1049699
Tinea pedis (athlete's foot) is a fungal infection that is both widespread and challenging to treat. Standard treatments consist of topical and systemic therapies of antifungal agents, such as miconazole, itraconazole, and terbinafine. The extended nature of topical therapy and the toxicity of long-term systemic therapy limit the utility of current treatments. An alternate approach relies on an understanding of bacterial–fungal interactions. Specifically, a probiotic antifungal bacterium such as Janthinobacterium lividum can counter infection; Janthinobacterium is a major constituent of the human skin microbiota. Janthinobacterium lividum has been shown to ameliorate the effects of the cutaneous fungal disease chytridiomycosis in a vertebrate species (Rana muscosa).
Dual-culture plate challenge assays were performed using J. lividum and Trichophyton rubrum, the leading cause of athlete's foot.
In all cases, T. rubrum colonies grew significantly smaller when co-cultured with J. lividum.
These in vitro results suggest that J. lividum merits further investigation as a human cutaneous probiotic.