Conflicts of interest: None.
Multiple linear leiomyomas of the forehead as the presenting sign of Reed syndrome
Article first published online: 30 SEP 2013
© 2013 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 3, pages 316–318, March 2014
How to Cite
Kakar, R., Davis, J. C. and Crowe, D. R. (2014), Multiple linear leiomyomas of the forehead as the presenting sign of Reed syndrome. International Journal of Dermatology, 53: 316–318. doi: 10.1111/ijd.12240
- Issue published online: 20 FEB 2014
- Article first published online: 30 SEP 2013
A 62-year-old female presented with a linear arrangement of multiple asymptomatic, discrete, dome-shaped, smooth, skin-colored papules and nodules involving the left forehead. Histopathology showed a poorly circumscribed nodule of haphazardly arranged fascicles of smooth muscle cells involving the papillary and superficial reticular dermis. Genetic testing revealed the patient to be heterozygous for the R233H mutation in the fumarate hydratase gene. Clinical, microscopic, and genetic findings were consistent with a diagnosis of Reed syndrome. Reed syndrome is a rare disorder defined by cutaneous and uterine leiomyomas and, uncommonly, renal cell carcinoma.