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Clinical efficacy and compliance of sublingual immunotherapy with Dermatophagoides farinae drops in patients with atopic dermatitis

Authors

  • Yu-E Qin MMED,

    Corresponding author
    1. International Health Care Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, China
    • Correspondence

      Yu-E Qin, mmed

      The International Health Care Center

      First Affiliated Hospital

      College of Medicine

      Zhejiang University

      Hang Zhou 310003

      China

      E-mail: qyeyoyo@126.com

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  • Jing-Ran Mao MMED,

    1. Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, China
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  • Yue-chan Sang MSc,

    1. Department of Clinical Sciences, Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd., Shanghai, China
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  • Wen-Xiu Li MSc

    1. Department of Clinical Sciences, Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd., Shanghai, China
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  • Conflicts of interest: None.

Abstract

Background

The oral route for administration of allergen immunotherapy has been explored since the 1900s. We attempted to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in patients with atopic dermatitis (AD) and investigate related factors influencing the patients' compliance.

Methods

A total of 107 patients with AD were randomized to receive either D. farinae drops plus pharmacotherapy (treatment group, n = 58) or only pharmacotherapy (control group, n = 49). Patients' compliance, the total effective rate, daily drug scores, visual analogue scale (VAS) scores, and IgG4 level were compared respectively between two groups at different time points.

Results

Twenty-three cases have withdrawn from the study. The total effective rate in the treatment group (77.78%) was significantly higher than the control group (53.85%) (< 0.05). The treatment group was significantly reduced in daily drug scores and VAS scores compared with the control group at 12 months follow-up. Meanwhile, at the end of therapy, a significant difference was found in the change in average daily drug scores (difference from 1 month) between two groups (< 0.01); The treatment group evidently had a higher level of serum-specific IgG4 than the control group at 6 and 12 month of treatment (< 0.05).

Conclusion

Dermatophagoides farinae drops are a safe and effective SLIT for patients with AD, which was proven to reduce the need for medicine. In addition, SLIT could induce a tolerogenic IgG4 response to mite allergen correlated with favorable clinical efficacy. Standardization of specific immunotherapy is essential to ensure therapeutic efficacy and compliance.

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