Funding sources: This review has no sources of funding.
Roseola infantum and its causal human herpesviruses
Article first published online: 14 FEB 2014
© 2014 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 4, pages 397–403, April 2014
How to Cite
Stone, R. C., Micali, G. A. and Schwartz, R. A. (2014), Roseola infantum and its causal human herpesviruses. International Journal of Dermatology, 53: 397–403. doi: 10.1111/ijd.12310
Conflicts of interest: None.
- Issue published online: 20 MAR 2014
- Article first published online: 14 FEB 2014
Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by infection with human herpesviruses 6 or 7 (HHV-6/7), which are acquired at a young age. Diagnosis is made by serology or by virus detection in body fluids and tissues. Treatment of roseola is supportive; recovery is usually complete with no significant sequelae. However, HHV-6/7 can reactivate in immunocompetent as well as immunocompromised individuals with severe systemic consequence.