Conflicts of interest: None.
Pharmacology and Therapeutics
Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial
Article first published online: 2 APR 2014
© 2014 The International Society of Dermatology
International Journal of Dermatology
Volume 53, Issue 9, pages 1157–1164, September 2014
How to Cite
El-Mofty, M., Mostafa, W. Z., Yousef, R., Abdel Halim, M. R. E., El Hawary, M., Abdel Kader, H., Assaad, S. and Ghannam, B. B. (2014), Broadband ultraviolet A in the treatment of psoriasis vulgaris: a randomized controlled trial. International Journal of Dermatology, 53: 1157–1164. doi: 10.1111/ijd.12317
- Issue published online: 14 AUG 2014
- Article first published online: 2 APR 2014
Broadband ultraviolet A (BB-UVA) has been successfully used in the treatment of scleroderma, a UVA1-responsive dermatosis.
To compare the efficacy of BB-UVA versus psoralen + UVA (PUVA) in psoriasis treatment and assess apoptosis as an effector mechanism.
Patients and methods
This randomized controlled trial included 61 patients with chronic plaque psoriasis randomly divided into group I or II. Group I were further randomized to either IA or IB who received UVA 10 or 15 J/cm2 per session, respectively, while group II received PUVA. Therapy was delivered thrice weekly until clearance or 48 treatments at most. The primary outcome measured was clearance of psoriasis. Dermal lymphocytic counts and bcl-2 expression were measured in 20 patients from each group.
Final Psoriasis Area Severity Index scores were reduced within each group. The UVA group achieved results comparable to PUVA until session 24 but failed to match it at final evaluation, with significantly better clinical, immunohistochemical, and histopathological results achieved by PUVA (P ≤ 0.05). Both modalities caused a reduction in dermal lymphocytic counts and epidermal bcl-2 expression.
BB-UVA appears to be safe and acceptable for the treatment of chronic plaque psoriasis possibly through bcl-2-mediated apoptosis of keratinocytes and epidermal lymphocytes.