Get access

Comparative study of the effect of narrowband ultraviolet B phototherapy plus methotrexate vs. narrowband ultraviolet B alone and methotrexate alone in the treatment of plaque-type psoriasis

Authors

  • Hayder R. Al-Hamamy MBCHB, DDV, PhD, CABD,

    1. Scientific Council of Dermatology, Iraqi Board for Medical Specializations, Baghdad, Iraq
    Search for more papers by this author
  • Sabeeh A. Al-Mashhadani MBCHB, MSC,

    1. Department of Dermatology and Venereology, College of Medicine, University of Baghdad, Baghdad, Iraq
    Search for more papers by this author
  • Ihsan N. Mustafa MBCHB, FIBMS

    Corresponding author
    1. Department of Dermatology and Venereology, College of Medicine, AL-Nahrain University, Baghdad, Iraq
    • Correspondence

      Dr. Ihsan N. Mustafa

      department of dermatology & venereology

      AL-Nahrain college of medicine.

      Baghdad

      Iraq

      E-mail: ihsannazar@yahoo.com

    Search for more papers by this author

  • The research was conducted in Baghdad teaching hospital.
  • Conflicts of interest: None.

Abstract

Background

Widespread psoriasis has great effects on life. Effective and rapid response in the treatment is needed. So this study was done to compare the efficacy of combined narrowband ultraviolet-B (NBUVB) plus methotrexate (MTX) versus each one alone in the treatment of psoriasis.

Methods

A total of 120 patients with widespread plaque-type psoriasis were enrolled, but only 113 patients completed the study. They were divided into three groups randomly, group MN (38) received NBUVB plus MTX, group N (38) received NBUVB alone, and group M (37) received MTX only. End point of treatment (clearance) was 90% reduction in Psoriasis Area and Severity Index (PASI) Score or up to six months, whichever was earlier; follow-up was done for one year.

Results

The mean number of weeks required for achieving clearance was 6.11 ± 1.28 weeks in group MN, 11.42 ± 2.36 weeks in group N, and 20.87 ± 4.21 weeks in group M (< 0.0001). The mean number of phototherapy sessions was 17.86 ± 3.74 sessions in group MN, and 33.51 ± 6.9 sessions in group N (< 0.0001). The mean total cumulative dose of NBUVB for achieving clearance was 12.13 ± 4.02 J/cm2 in group MN, compared with 34.48 ± 13.13 J/cm2 in group N (< 0.0001), while the mean total cumulative dose of MTX was 116.04 ± 20.47 mg in group MN compared with 298.63 ± 60.26 mg in group M (< 0.0001).

Conclusions

Combination of NBUVB plus MTX provided rapid improvement with less cumulative doses of both therapies compared with each one alone in the treatment of psoriasis.

Ancillary