Cutaneous stigmata associated with insulin resistance and increased cardiovascular risk

Authors

  • William H. K. Schilling MB, BS,

    1. Clinical Biochemistry and Metabolic Medicine, University Hospital Lewisham and Guy's and St Thomas' Hospital, London, UK
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  • Martin A. Crook BSc, MB, BS, MA, PhD, FRCPath FRCPI, FRCP

    Corresponding author
    1. Clinical Biochemistry and Metabolic Medicine, University Hospital Lewisham and Guy's and St Thomas' Hospital, London, UK
    • Correspondence

      Professor Martin A. Crook, bsc, mb, bs, ma, PhD, FRCPath FRCPI, FRCP

      Department of Clinical Biochemistry

      University Hospital Lewisham

      Lewisham

      London SE13 6LH

      UK

      E-mail: martin.crook@doctors.org.uk

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  • Funding: None.
  • Conflicts of interest: None.

Abstract

Certain cutaneous conditions have been reported to be associated with diabetes mellitus, insulin resistance, and metabolic syndrome. In this novel review paper, the evidence linking various cutaneous phenomena (e.g. skin tags, acanthosis nigricans, ear lobe creases, and xanthelasma) and metabolic syndrome and cardiovascular disease is examined, and explanations for these associations are proposed.

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