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MDR1 C3435T polymorphism associated with the development of clinical features in Behçet's disease in Iranian Azeri Turkish patients

Authors

  • Mortaza Bonyadi PhD,

    Corresponding author
    1. Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
    2. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    • Correspondence

      Mortaza Bonyadi, PhD

      Center of Excellence for Biodiversity

      Faculty of Natural Sciences

      University of Tabriz

      Tabriz 51656-39758

      Iran

      E-mail: jabbarpour@tabrizu.ac.ir

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  • Monireh Gholizadeh MSc,

    1. Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
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  • Mahboob Soltan-Ali PhD

    1. Department of Community and Family Medicine, School of Medicine, National Public Health Management Centre, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Conflicts of interest: None.

Abstract

Background

Behçet's disease (BD) is a systemic vasculitis of unknown cause with a higher prevalence along the ancient Silk Road. Behçet's occasional familial aggregation and its close association with genes of major histocompatibility complexes justify that genetic factors play an important role in the development of the disease. In this study, we evaluated the association of multidrug resistance (MDR1) C3435T polymorphism with the severity of BD.

Method

We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex-matched healthy controls, via the polymerase chain reaction–restriction fragment length polymorphism technique.

Result

Although there was no significant association of MDR1 C3435T polymorphism between two groups of patients and healthy controls, our data showed a substantial association of CC genotype with the development of several clinical features, including erythema nodosum (P = 0.001, OR = 2.686, 95%), pseudofolliculitis (P = 0.002, OR = 2.812, 95%), and skin lesions (P = 0.040, OR = 1.934, 95%).

Conclusion

These results suggest that CC genotype is a risk factor for the development of some clinical features of BD in patients from the Iranian Azeri Turk ethnic group.

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