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Figure S1. Thermal inactivation of LOX at temperatures from 50°C to 80°C at ambient pressure.

Figure S2. High hydrostatic pressure inactivation of LOX.

Figure S3. The effect of temperature on the activation volume (Va) values of LOX.

Figure S4. High hydrostatic pressure inactivation of LOX. Effect of process temperature (from 50°C to 80°C) at a constant pressure 500 MPa.

Figure S5. The effect of pressure on the activation energy (Ea) values of LOX.

Figure S6. Response surface and contour plots, fitted to the experimental data points, corresponding to LOX inactivation rate constants (k) as a function of temperature (°C) and pressure (MPa).

Table S1. LOX inactivation rate constants (×10-2min-1) at different pressure and temperature process conditions.

Table S2. Experimental design matrix in terms of actual variables and the average values of the responses for the experiment on the effects of combined high pressure-temperature processing on the LOX inactivation rate constant in crude silver carp extract.

Table S3. Analysis of variance and coefficients of the response surface models describing the effects of combined high pressure-temperature processing on the LOX inactivation rate constant in crude silver carp extract after eliminating non-significant terms.

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