HLA-G 5′ URR SNPs and 3′ UTR 14-bp insertion/deletion polymorphism in an Afro-Brazilian population from Paraná State

Authors

  • L. V. Tureck,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • L. C. Santos,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • P. F. Wowk,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
    Current affiliation:
    1. Carlos Chagas Institute, ICC/Fiocruz-PR, Curitiba, Brazil
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  • S. B. Mattar,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • J. S. Silva,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • J. C. M. Magalhães,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • V. M. M. S. Roxo,

    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
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  • M. G. Bicalho

    Corresponding author
    1. Department of Genetics, Laboratory of Immunogenetics and Histocompatibility, Universidade Federal do Paraná, Curitiba, Brazil
    • Correspondence: Maria da Graça Bicalho, Laboratório de Imunogenética e Histocompatibilidade, Departamento de Genética, Universidade Federal do Paraná, R. Cel. Francisco H. dos Santos S/N, Centro Politécnico – Jardim das Américas, CP 19071, CEP 81.530-990, Curitiba – PR, Brazil. Tel: +55 41 3361 1729; Fax: +55 41 3266 2042; E-mail: ligh@ufpr.br

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Summary

The present study investigated 23 SNPs in the 5′URR promoter region and the 14 bp ins/del polymorphism at the 3′UTR region of the HLA-G gene in 150 individuals with Afro-Brazilian ancestry. Three haplotypes were found to be the most frequent. Comparing these polymorphisms in other samples, our data suggest that Afro-Brazilians are more similar to the Euro-Brazilians than to Hutterite population.

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