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Medication adherence feedback intervention predicts improved human immunodeficiency virus clinical markers


  • Warren Reich is the Research and Evaluation Manager at The Family Center in New York City.
  • I wish to thank Paul Boxer, David Holtgrave, Jan Hudis, Andrea Vial, and Dave Nimmons for their comments on an earlier version of this paper, and to Julia Sanchez, Ikponmwosa Edorisiagbon, and Stephanie Mendez for their assistance in data collection. This research was supported in part by a grant from the Pfizer Foundation.


Thirty-three participants in a human immunodeficiency virus (HIV) medication adherence feedback (MAF) intervention were compared with 58 HIV-positive non-participants in laboratory-tested CD4 and viral load. The intervention provided adherence feedback and counselling based on a visual display from an electronic pill bottle (MEMSTM). Multiple regression controlling for baseline CD4 and showed that postintervention CD4 was higher for MAF participants than for non-MAF participants. Non-MAF participants' CD4 significantly declined over time. MAF participants were also less likely than non-MAF participants to have a detectable postintervention viral load.