Conflict of interest: None declared.
Stroke incidence and 30-day and six-month case fatality rates in Udine, Italy: a population-based prospective study
Version of Record online: 21 MAR 2013
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization
International Journal of Stroke
Special Issue: World Stroke Day Edition 2013
Volume 8, Issue Supplement A100, pages 100–105, October 2013
How to Cite
Janes, F., Gigli, G. L., D'Anna, L., Cancelli, I., Perelli, A., Canal, G., Russo, V., Zanchettin, B. and Valente, M. (2013), Stroke incidence and 30-day and six-month case fatality rates in Udine, Italy: a population-based prospective study. International Journal of Stroke, 8: 100–105. doi: 10.1111/ijs.12000
Funding: The study has been made possible, thanks to a grant of the Italian Ministry of Health (PRF 18-06).
- Issue online: 22 OCT 2013
- Version of Record online: 21 MAR 2013
- Italian Ministry of Health. Grant Number: PRF 18-06
- intracerebral hemorrhage;
- ischemic stroke;
- stroke sub-types;
- vascular events
Stroke incidence in high-income countries is reported to decrease, and new data on stroke incidence and outcome are needed to design stroke services and to ameliorate stroke management.
This study is part of a two-year prospective community-based registry of all cerebrovascular events in the district of Udine (153 312 inhabitants), Friuli-Venezia Giulia region, northeast of Italy, between 1 April 2007 and 31 March 2009. Overlapping sources for case finding were used, combining hot and cold pursuit.
We identified 784 stroke cases, 640 (81·6%) incident. The crude overall annual incidence rate per 100 000 residents was 256 (95% confidence interval 241–271) for all strokes and 209 (95% confidence interval 195–223) for first-ever strokes. Incidence rate for first-ever strokes was 181 (95% confidence interval 155–211) after adjustment to the 2007 Italian population and 104 (95% confidence interval 88–122) compared with the European standard population. Incidence rates for first-ever strokes was 215 (196–235) for women, 202 (183–223) for men. Crude annual incidence rates per 100 000 population were 167 (153–178) for ischemic stroke, 31 (26–37) for intracerebral hemorrhage, 8·1 (5·7–11·4) for sub-arachnoid hemorrage, and 4·6 (2·8–7·1) for undetermined stroke. Overall case fatality rates for first-ever stroke were 20·6% at 28 days and 30·2% at 180 days.
Our study shows incidence rates higher than previously reported in our region but not supporting the view of higher incidence rates in Northern than in Southern Italy. Results contribute to time-trends analysis on epidemiology, useful for dimensioning services in Italy and show the persistence of a gap between the outcome of stroke in Italy and that of the best performing European countries, urging to adopt better stroke management plans.