• 1
    Hacke W, Donnan G, Fieschi Cet al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS Rt-PA stroke trials. Lancet 2004; 363:768774.
  • 2
    Lees KR, Bluhmki E, von Kummer Ret al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375:16951703.
  • 3
    Davis SM, Donnan GA, Parsons MWet al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008; 7:299309.
  • 4
    Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischemic stroke. Stroke 2010; 41:e445e446.
  • 5
    Lorenzano S, Danilo T, for the TESPI trial Investigators. TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt-PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after stroke onset. Int J Stroke 2012; 7:250257.
  • 6
    IST-3 collaborative group. Statistical analysis plan for the third International Stroke Trial (IST-3); part of a ‘thread’ of reports of the trial. Int J Stroke 2012; 7:186187.
  • 7
    Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York, Wiley, 1987.
  • 8
    Sterne JA, White IR, Carlin JBet al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 2009; 338:b2393.
  • 9
    The European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008; 25:457507.
  • 10
    Mishra NK, Ahmed N, Andersen Get al.; VISTA Collaborators; SITS Collaborators. Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ 2010; 341:c6046. doi: 10.1136/bmj.c6046.
  • 11
    Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR; VISTA Collaborators. Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA). Stroke 2010; 41:28402848.
  • 12
    Ford GA, Ahmed N, Azevedo Eet al. Intravenous alteplase for stroke in those older than 80 years old. Stroke 2010; 41:25682574.
  • 13
    Summary of product characteristics (alteplase). Available at (accessed 13 March 2012).
  • 14
    Mishra NK, Lyden P, Grotta JC, Lees KR, for the VISTA Collaborators. Thrombolysis is associated with consistent functional improvement across baseline stroke severity: a comparison of outcomes in patients from the Virtual International Stroke Trials Archive (VISTA). Stroke 2010; 41:26122617.
  • 15
    Murray GD, Barer D, Choi Set al. Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy. J Neurotrauma 2005; 22:511517.
  • 16
    Howard G, Waller JL, Voeks JHet al. A simple, assumption-free, and clinically interpretable approach for analysis of modified rankin outcomes. Stroke 2012; 43:664669.