With the support of Iberoamerican Cerebrovascular Diseases Society.
Strategies of recovery
Strategies to improve recovery in acute ischemic stroke patients: Iberoamerican Stroke Group Consensus
Article first published online: 27 JUN 2013
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization
International Journal of Stroke
Volume 9, Issue 4, pages 503–513, June 2014
How to Cite
Alonso de Leciñana, M., Gutiérrez-Fernández, M., Romano, M., Cantú-Brito, C., Arauz, A., Olmos, L., Ameriso, S., Díez-Tejedor, E. and Iberoamerican Stroke Group (2014), Strategies to improve recovery in acute ischemic stroke patients: Iberoamerican Stroke Group Consensus. International Journal of Stroke, 9: 503–513. doi: 10.1111/ijs.12070
Conflicts of interest: The authors declare no potential conflict of interest.
Disclosures: Different members have received consultant fees and/or travel stipends from and have collaborated as speakers or researchers with the following companies: Astra-Zeneca, Bayer, Bristol- Myers Squibb, Boehringer Ingelheim, Cellerix, Ferrer Grupo, Brainsgate, Merck/ MSD, Raffo, Pfizer, Sanofi, Sygnis Pharma AG, and EVER Neuro Pharma.
- Issue published online: 5 MAY 2014
- Article first published online: 27 JUN 2013
- Manuscript Accepted: 31 OCT 2012
- Manuscript Received: 3 AUG 2012
- brain plasticity;
- brain protection;
- brain repair;
- ischemic stroke
Stroke is not only a leading cause of death worldwide but also a main cause of disability. In developing countries, its burden is increasing as a consequence of a higher life expectancy. Whereas stroke mortality has decreased in developed countries, in Latin America, stroke mortality rates continue to rise as well as its socioeconomic dramatic consequences. Therefore, it is necessary to implement stroke care and surveillance programs to better describe the epidemiology of stroke in these countries in order to improve therapeutic strategies. Advances in the understanding of the pathogenic processes of brain ischemia have resulted in development of effective therapies during the acute phase. These include reperfusion therapies (both intravenous thrombolysis and interventional endovascular approaches) and treatment in stroke units that, through application of management protocols directed to maintain homeostasis and avoid complications, helps to exert effective brain protection that decreases further cerebral damage. Some drugs may enhance protection, and besides, there is increasing knowledge about brain plasticity and repair mechanisms that take place for longer periods beyond the acute phase. These mechanisms are responsible for recovery in certain patients and are the focus of basic and clinical research at present. This paper discusses recovery strategies that have demonstrated clinical effect, or that are promising and need further study. This rapidly evolving field needs to be carefully and critically evaluated so that investment in patient care is grounded on well-proven strategies.