Both authors contributed equally to the work.
The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
Article first published online: 9 JUL 2013
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization
International Journal of Stroke
Volume 9, Issue 3, pages 387–392, April 2014
How to Cite
Wollenweber, F. A., Zietemann, V., Rominger, A., Opherk, C., Bayer-Karpinska, A., Gschwendtner, A., Coloma Andrews, L., Bürger, K., Duering, M. and Dichgans, M. (2014), The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data. International Journal of Stroke, 9: 387–392. doi: 10.1111/ijs.12092
Conflict of interest:
Dr. Wollenweber reports no conflicts of interest.
Dr. Zietemann reports no conflicts of interest.
Dr. Rominger received support from Bayer, GE and Octapharm AG.
Dr. Opherk receives research support from the Deutsche Forschungsgemeinschaft and the Dr. Werner Jackstädt Foundation; has served on scientific advisory boards for Boehringer-Ingelheim and Bristol-Myers Squibb and has received speaker honoraria from Bayer, Boehringer-Ingelheim and MSD Sharp Dohme.
Dr. Bayer-Karpinska reports no conflicts of interest.
Dr. Gschwendtner reports no conflicts of interest.
Dr. Coloma Andrews reports no conflicts of interest.
Dr. Bürger receives speaker honoraria from Novartis and Merz.
Dr. Duering reports no conflicts of interest.
Dr. Dichgans receives research support from the European Union, the Deutsche Forschungsgemeinschaft, the BMBF, the German Center for Neurodegenerative Diseases, the Vascular Dementia Research Foundation, the Dr. Werner Jackstädt Foundation, the Corona Foundation, and the Fondation Leducq. He is a consultant to Bayer Vital GmbH; Boehringer Ingelheim Pharma GmbH & Co. KG; Biologische Heilmittel Heel GmbH; Bristol-Myers Squibb GmbH & Co. KGaA; Ever Neuro Pharma GmbH. He has received honoraria from Bayer Vital GmbH, Boehringer Ingelheim Pharma GmbH & Co. KG, Biologische Heilmittel Heel GmbH, Ever Neuro Pharma GmbH; Bristol-Myers Squibb GmbH & Co. KGaA, Lundbeck GmbH, Sanofi-Aventis Deutschland GmbH, Shire Deutschland GmbH, UpToDate, W. Kohlhammer GmbH.
- Issue published online: 17 MAR 2014
- Article first published online: 9 JUL 2013
- Manuscript Accepted: 30 JAN 2013
- Manuscript Received: 26 AUG 2012
- poststroke dementia;
- poststroke dementia epidemiology;
- stroke-related outcomes
About 20% of stroke patients develop dementia within a few months after their event, but the determinants and mechanisms of poststroke dementia are insufficiently understood.
To identify and characterize the determinants of cognitive impairment poststroke.
Observational prospective study in patients with acute stroke and no prior dementia. Six hundred subjects will be characterized by detailed interview, standardized clinical examinations, biometric measures (intima-media thickness, waist-hip ratio, and ankle-brachial index), multimodal imaging (magnetic resonance imaging, fluorodeoxyglucose-positron emission tomography (FDG-PET), amyloid-positron emission tomography (amyloid-PET), and retinal imaging), analysis of biomarkers derived from blood and cerebrospinal fluid, and detailed cognitive testing at repeat time points. Patients will be followed for five-years with a total of five personal visits and three telephone interviews.
Primary end-point is the occurrence of poststroke dementia. Secondary end-points include poststroke cognitive impairment–no dementia, stroke recurrence, and death. Predictive factors for poststroke dementia will be identified by multiple Cox proportional-hazards model.
Baseline characteristics of the first 71 patients (study inclusion between May 2011 and August 2012) are as follows: median age, 70 years (interquartile range, 65–75); female gender, 25 (35%); median National Institutes of Health Stroke Scale at admission, 2 (1–4); and etiological stroke subtypes according to TOAST classification, 15% large artery disease, 18% small vessel disease, 35% cardioembolic, and 32% undetermined or multiple competing etiologies.
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.