Conflict of interest: The authors report no conflicts of interest.
Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack
Article first published online: 26 AUG 2013
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization
International Journal of Stroke
Volume 9, Issue 4, pages 413–418, June 2014
How to Cite
Tsivgoulis, G., Sharma, V. K., Mikulik, R., Krogias, C., Haršány, M., Bavarsad Shahripour, R., Athanasiadis, D., Teoh, H. L., Piperidou, C. and Alexandrov, A. V. (2014), Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack. International Journal of Stroke, 9: 413–418. doi: 10.1111/ijs.12125
- Issue published online: 5 MAY 2014
- Article first published online: 26 AUG 2013
- Manuscript Accepted: 19 MAR 2013
- Manuscript Received: 30 DEC 2012
- European Regional Development Fund. Grant Number: CZ.1·05/1·1.00/02·0123
- acute ischemic stroke;
- intravenous thrombolysis;
- transient ischemic attack
There are limited data regarding the use of intravenous thrombolysis in patients who experienced acute ischemic symptoms during their hospitalization for prior transient ischemic attack.
We sought to prospectively evaluate the safety and efficacy of intravenous thrombolysis for the treatment of acute ischemic stroke occurring during hospitalization for transient ischemic attack in an international, multicenter study.
Consecutive patients with acute ischemic stroke that occurred during hospitalization for prior transient ischemic attack were treated with intravenous thrombolysis in five tertiary-care stroke centers. Early arterial recanalization was determined by transcranial Doppler at the end of recombinant tissue plasminogen activator infusion using previously validated criteria. Symptomatic intracranial hemorrhage complicating intravenous thrombolysis was evaluated using the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study definition. Functional independence at three-months was defined as Modified Rankin Scale score of 0–2.
Systemic recombinant tissue plasminogen activator infusion (median onset-to-treatment time 70 mins, interquartile range 50–150) was given in 25 consecutive patients (mean age 66 ± 10 years) who developed acute ischemic stroke symptoms (median National Institutes of Health Stroke Scale score 10 points; interquartile range 8–14) during hospitalization for prior transient ischemic attack (median ABCD2 score 5 points; median time-to-symptom recurrence 24 h, interquartile range 24–48). No symptomatic intracranial hemorrhage (0%; 95% confidence interval 0–12%) was documented. Early complete recanalization occurred in 64% of patients (95% confidence interval 44–80%), and 84% (95% confidence interval 65–94%) achieved three-month functional independence. The rate of three-month functional independence was higher in patients treated with intravenous tissue plasminogen activator within 90 mins from symptom onset compared with those with onset-to-treatment time>90 mins (81% vs. 33%; P = 0·031).
Intravenous thrombolysis for symptoms of acute ischemic stroke occurring after hospitalization for transient ischemic attack appears to be safe. These pilot data support resetting the clock if new symptoms recur shortly after transient ischemic attack.