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Keywords:

  • acute stroke therapy;
  • hamartin;
  • ischemic stroke;
  • neuroprotection;
  • productive autophagy;
  • treatment

Tuberous sclerosis complex 1 (hamartin) is an effective endogenous neuroprotectant. Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions.