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References

  • 1
    van der Worp HB, van Gijn J. Acute ischemic stroke. N Engl J Med 2007; 357:572579.
  • 2
    O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Ann Neurol 2006; 59:467477.
  • 3
    Watanabe T, Morita I, Nishi H, Murota SI. Preventive effect of mci-186 on 15-hpete induced vascular endothelial cell injury in vitro. Prostaglandins Leukot Essent Fatty Acids 1988; 33:8187.
  • 4
    Yoshida H, Sasaki K, Namiki Y, Sato N, Tada N. Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (ldl) and reverses oxidized ldl-mediated reduction in the expression of endothelial nitric oxide synthase. Atherosclerosis 2005; 179:97102.
  • 5
    Ishii J, Natsume A, Wakabayashi T et al. The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress. Neurosci Lett 2007; 423:225230.
  • 6
    Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res 2010; 1307:2227.
  • 7
    Ikeda T, Xia YX, Kaneko M, Sameshima H, Ikenoue T. Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (mci-186), on hypoxia-ischemia-induced brain injury in neonatal rats. Neurosci Lett 2002; 329:3336.
  • 8
    Nakamura T, Kuroda Y, Yamashita S et al. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke 2008; 39:463469.
  • 9
    Nakagomi T, Yamakawa K, Sasaki T, Saito I, Takakura K. Effect of edaravone on cerebral vasospasm following experimental subarachnoid hemorrhage. J Stroke Cerebrovasc Dis 2003; 12:1721.
  • 10
    Wang GH, Jiang ZL, Li YC et al. Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats. J Neurotrauma 2011; 28:21232134.
  • 11
    Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 1988; 19:480485.
  • 12
    Nishi H, Watanabe T, Sakurai H, Yuki S, Ishibashi A. Effect of mci-186 on brain edema in rats. Stroke 1989; 20:12361240.
  • 13
    Oishi R, Itoh Y, Nishibori M, Watanabe T, Nishi H, Saeki K. Effect of mci-186 on ischemia-induced changes in monoamine metabolism in rat brain. Stroke 1989; 20:15571564.
  • 14
    Otomo E, Tohgi H, Kogure K et al. Clinical efficacy of a free radical scavenger, mci-186, on acute cerebral infarction: early phase ii clinical trial. Ther Res 1998; 19:13111332.
  • 15
    Otomo E. Effect of a novel free radical scavenger, edaravone (mci-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003; 15:222229.
  • 16
    Shinohara Y, Saito I, Kobayashi S, Uchiyama S. Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (edo trial). Cerebrovasc Dis 2009; 27:485492.
  • 17
    Feng S, Yang Q, Liu M, et al. Edaravone for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD007230. DOI: 10.1002/14651858.CD007230.pub2.
  • 18
    Green AR, Ashwood T. Free radical trapping as 1a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with nxy-059 and free radical scavengers. CNS & Neurological Disorders – Drug Targets 2005; 4:109118.
  • 19
    Macleod MR, O'Collins T, Howells DW, Donnan GA. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 2004; 35:12031208.
  • 20
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177188.
  • 21
    Light RJ, Pillemer DB. Summing up: The Science of Reviewing Research. Cambridge, Massachusetts, USA, Harvard University Press, 1984.
  • 22
    Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629634.
  • 23
    Duval S, Tweedie R. A nonparametric‘ trim and fill’ method of accounting for publication bias in meta-analysis. J Am Stat Assoc 2000; 95:8998.
  • 24
    Xu C, Tao Y. Protective effects of edaravone against ischemia-induced endoplasmic reticulum stress in rats. Pharm Care and Res 2009; 9:452454.
  • 25
    Kito G, Yoshikawa T, Susumu T, Nagata R. Neuroprotective effect of edaravone, a radical scavenger, in thromboembolic stroke model in primates. Stroke 2004; 35:282282.
  • 26
    Lapchak PA, Zivin JA. Efficacy of edaravone (radicut) in combination with tissue plasminogen activator in a rabbit embolic stroke model. Stroke 2009; 40:E255E255.
  • 27
    Shintaku K, Honjo K, Hu JQ, Yuki S, Satoh H, Misu Y. Long-term effect of edaravone, a neuroprotective agent, on the functional outcome in a non-human primate model of stroke. J Pharmacol Sci 2005; 97:210PP.
  • 28
    Watanabe T, Yuki S, Saito K, Sato S, Sugimoto J, Ohori Y. Pharmacological studies of mci-186, a new drug for acute stroke. Japanese Pharmacology and Therapeutics 1997; 25:181188.
  • 29
    Yoshikawa T. Neuroprotective effects of edaravone combined with tissue plasminogen activator (t-pa) in a primate thrombolic stroke model. Stroke 2004; 35:E253E253.
  • 30
    Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of mci-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994; 268:15971604.
  • 31
    Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20:8491.
  • 32
    Bederson JB, Pitts LH, Tsuji M, Nishimura M, Davis R, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986; 17:472476.
  • 33
    Yamashita T, Kamiya T, Deguchi K et al. Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain. J Cereb Blood Flow Metab 2009; 29:715725.
  • 34
    Jiao L, Zhang J, Li Z, Liu H, Chen Y, Xu S. Edaravone alleviates delayed neuronal death and long-dated cognitive dysfunction of hippocampus after transient focal ischemia in wistar rat brains. Neuroscience 2011; 182:177183.
  • 35
    Fisher M, Feuerstein G, Howells DW et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009; 40:22442250.
  • 36
    Sena E, Wheble P, Sandercock P, Macleod M. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke. Stroke 2007; 38:388394.
  • 37
    Kontos HA. Oxygen radicals in cerebral ischemia: the 2001 willis lecture. Stroke 2001; 32:27122716.
  • 38
    Sano Y, Motomura T, Yamamoto F, Fukuda M, Mukai T, Maeda M. 1-(3′-[125i]iodophenyl)-3-methy-2-pyrazolin-5-one: preparation, solution stability, and biodistribution in normal mice. Chem Pharm Bull (Tokyo) 2010; 58:10201025.
  • 39
    Zhang WR, Sato K, Hayashi T et al. Extension of ischemic therapeutic time window by a free radical scavenger, edaravone, reperfused with tpa in rat brain. Neurol Res 2004; 26:342348.
  • 40
    O'Collins VE, Macleod MR, Donnan GA, Howells DW. Evaluation of combination therapy in animal models of cerebral ischemia. J Cereb Blood Flow Metab 2012; 32:585597.
  • 41
    Sena ES, van der Worp HB, Bath PMW, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 2010; 8:e1000344.
  • 42
    van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 2007; 130:30633074.
  • 43
    Takeshita H, Okuda Y, Sari A. The effects of ketamine on cerebral circulation and metabolism in man. Anesthesiology 1972; 36:6975.
  • 44
    Bath P, Macleod M, Green A. Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. International Journal of Stroke 2009; 4:471479.
  • 45
    Dirnagl U, Fisher M. International, multicenter randomized preclinical trials in translational stroke research: it's time to act. J Cereb Blood Flow Metab 2012; 32:933935.