Conflicts of interest: B. C. V. Campbell received speaker's honoraria from Boehringer Ingelheim and acted as a consultant for Lundbeck. I. M. Macrae has nothing to declare.
Translational perspectives on perfusion–diffusion mismatch in ischemic stroke
Version of Record online: 11 NOV 2013
© 2013 The Authors. International Journal of Stroke published by John Wiley & Sons Ltd on behalf of World Stroke Organization.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
International Journal of Stroke
Volume 10, Issue 2, pages 153–162, February 2015
How to Cite
Campbell, B. C. V. and Macrae, I. M. (2015), Translational perspectives on perfusion–diffusion mismatch in ischemic stroke. International Journal of Stroke, 10: 153–162. doi: 10.1111/ijs.12186
- Issue online: 19 JAN 2015
- Version of Record online: 11 NOV 2013
- diffusion imaging;
- perfusion imaging;
- thrombolytic therapy
Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials. However, recent analyses of the major clinical studies have led to refinements in selection criteria and improved understanding of the potential implications for the risk vs. benefit of thrombolytic therapy. In parallel, preclinical studies have provided complementary information on the evolution of stroke that is difficult to obtain in humans due to the requirement for continuous or repeated imaging and pathological verification. We review the clinical and preclinical advances that have led to perfusion–diffusion mismatch being applied in phase 3 randomized trials and, potentially, future routine clinical practice.