• 1
    Lees KR, Bluhmki E, von Kummer R et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375:16951703.
  • 2
    Bhatia R, Hill MD, Shobha N et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke. Real-world experience and a call for action. Stroke 2010; 41:22542258.
  • 3
    Saqqur M, Uchino K, Demchuk AM et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007; 38:948954.
  • 4
    Broderick JP, Palesch YY, Demchuk AM et al. Endovascular therapy after intravenous t-PA versus t-PA Alone for stroke. N Engl J Med 2013; 368:893903.
  • 5
    Ciccone A, Valvassori L, Nichelatti M et al. Endovascular treatment for acute ischemic stroke. N Engl J Med 2013; 368:904913.
  • 6
    Parsons MW, Christensen S, McElduff P et al. Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab 2010; 30:12141225.
  • 7
    Yoo AJ, Verduzco LA, Schaefer PW, Hirsch JA, Rabinov JD, Gonzalez GG. MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke 2009; 40:20462054.
  • 8
    Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA. Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology 2009; 73:10661072.
  • 9
    Ribo M, Flores A, Rubiera M et al. Extending the time window for endovascular procedures according to collateral pial circulation. Stroke 2011; 42:34653469.
  • 10
    Pereira VM, Gralla J, Davalos A et al. Prospective, multicenter, single-arm study of mechanical thrombectomy using Solitaire flow restoration in acute ischemic stroke. Stroke 2013; ePub 1 Aug 2013 doi: 10.1161/STROKEAHA.113.001232.
  • 11
    Saver JL, Jahan R, Levy EI et al. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 2012; 380:12411249.
  • 12
    Miteff F, Levi CR, Bateman GA, Spratt N, McElduff P, Parsons MW. The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke. Brain 2009; 132(Pt 8):22312238.
  • 13
    Campbell BCV, Christensen S, Tress B et al. Failure of collateral blood flow is associated with infarct growth in ischemic stroke. J Cereb Blood Flow Metab 2013; 33:11681172.
  • 14
    Parsons MW, Barber PA, Chalk J et al. Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann Neurol 2002; 51:2837.
  • 15
    Davis SM, Donnan GA, Parsons MW et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008; 7:299309.
  • 16
    Olivot JM, Mlynash M, Thijs VN et al. Relationships between infarct growth, clinical outcome, and early recanalization in diffusion and perfusion imaging for understanding stroke evolution (DEFUSE). Stroke 2008; 39:22572263.
  • 17
    Barber PA, Darby DG, Desmond PM et al. Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI. Neurology 1998; 51:418426.
  • 18
    Albers GW, Thijs VN, Wechsler L et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006; 60:508517.
  • 19
    Lansberg MG, Straka M, Kemp S et al. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012; 11:860867.
  • 20
    Mishra NK, Albers GW, Davis SM et al. Mismatch-based delayed thrombolysis: a meta-analysis. Stroke 2010; 41:e2533.
  • 21
    Campbell BCV, Christensen S, Foster SJ et al. Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis. Cerebrovasc Dis 2010; 29:592596.
  • 22
    Fiebach JB, Al-Rawi Y, Wintermark M et al. Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke 2012; 43:15611566.
  • 23
    Warach S, Al-Rawi Y, Furlan AJ et al. Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials. Stroke 2012; 43:23132318.
  • 24
    Kidwell CS, Jahan R, Gornbein J et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013; 68:914923.
  • 25
    Christensen S, Campbell BCV, Perez de la Ossa N et al. Optimal perfusion thresholds for prediction of tissue destined for infarction in the combined EPITHET and DEFUSE dataset. Stroke 2010; 41:e297.
  • 26
    Olivot JM, Mlynash M, Thijs VN et al. Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke 2009; 40:469475.
  • 27
    Zaro-Weber O, Moeller-Hartmann W, Heiss WD, Sobesky J. Maps of time to maximum and time to peak for mismatch definition in clinical stroke studies validated with positron emission tomography. Stroke 2010; 41:28172821.
  • 28
    Christensen S, Parsons MW, De Silva DA et al. Optimal mismatch definitions for detecting treatment response in acute stroke. Cerebrovasc Dis 2008; 25(Suppl. 2):33.
  • 29
    Chemmanam T, Campbell BCV, Christensen S et al. Ischemic diffusion lesion reversal is uncommon and rarely alters perfusion-diffusion mismatch. Neurology 2010; 75:10401047.
  • 30
    Campbell BCV, Purushotham A, Christensen S et al. The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent. J Cereb Blood Flow Metab 2012; 32:5056.
  • 31
    Campbell BCV, Christensen S, Levi CR et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke 2011; 42:34353440.
  • 32
    Campbell BCV, Christensen S, Levi CR et al. Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke. Stroke 2012; 43:26482653.
  • 33
    Straka M, Albers GW, Bammer R. Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging 2010; 32:10241037.
  • 34
    Parsons MW, Spratt N, Bivard A et al. A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 2012; 366:10991107.
  • 35
    Campbell BC, Tu HT, Christensen S et al. Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging. Arch Neurol 2012; 69:4650.
  • 36
    Wintermark M, Albers GW, Broderick JP et al. Acute stroke imaging research roadmap II. Stroke 2013; 44:26282639.
  • 37
    Wahlgren N, Ahmed N, Davalos A et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007; 369:275282.
  • 38
    Mehta CR, Pocock SJ. Adaptive increase in sample size when interim results are promising: a practical guide with examples. Stat Med 2011; 30:32673284.
  • 39
    Holm S. A simple sequentially rejective multiple test procedure. Scand J Statist 1979; 6:6570.