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  • 1
    Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22:391397.
  • 2
    Lees KR, Bluhmki E, von Kummer R et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet [Meta-Analysis] 2010; 375:16951703.
  • 3
    Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982; 11:491498.
  • 4
    O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Ann Neurol 2006; 59:467477.
  • 5
    Kollmar R, Gebhardt B, Schwab S. [EuroHYP-1 trial : EU-funded therapy study on the effectiveness of mild therapeutic hypothermia for acute ischemic stroke.]. Nervenarzt 2012; 83:12521259.
  • 6
    Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 2010; 8:e1000344.
  • 7
    Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke 2008; 39:28242829.
  • 8
    Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab 2005; 25:713721.
  • 9
    Antonic A, Howells DW. Human in vitro models of ischaemic stroke: a test bed for translation. Translational Stroke Research 2012; 3:306309.
  • 10
    Zhao S, Shetty J, Hou L et al. Human, mouse, and rat genome large-scale rearrangements: stability versus speciation. Genome Res 2004; 14(10A):18511860.
  • 11
    Davalos A, Castillo J, Serena J, Noya M. Duration of glutamate release after acute ischemic stroke. Stroke [Research Support, Non-U.S. Gov't] 1997; 28:708710.
  • 12
    Takagi K, Ginsberg MD, Globus MY et al. Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: correlation with histopathology. J Cereb Blood Flow Metab 1993; 13:575585.
  • 13
    Nilupul Perera M, Ma HK, Arakawa S et al. Inflammation following stroke. J Clin Neurosci 2006; 13:18.
  • 14
    Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J Cereb Blood Flow Metab 2010; 30:19051913.
  • 15
    Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in acute ischemic stroke trials through the 20th century. Stroke 2001; 32:13491359.
  • 16
    Ferguson KN, Kidwell CS, Starkman S, Saver JL. Hyperacute treatment initiation in neuroprotective agent stroke trials. J Stroke Cerebrovasc Dis 2004; 13:109112.
  • 17
    Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1999; 30:27522758.
  • 18
    Gladstone DJ, Black SE, Hakim AM, Heart, Stroke Foundation of Ontario Centre of Excellence in Stroke R. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002; 33:21232136.
  • 19
    O'Collins VE, Macleod MR, Donnan GA, Howells DW. Evaluation of combination therapy in animal models of cerebral ischemia. J Cereb Blood Flow Metab [Review] 2012; 32:585597.
  • 20
    van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain 2007; 130:30633074.
  • 21
    Zhao H, Steinberg GK, Sapolsky RM. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage. J Cereb Blood Flow Metab 2007; 27:18791894.
  • 22
    Yenari M, Kitagawa K, Lyden P, Perez-Pinzon M. Metabolic downregulation: a key to successful neuroprotection? Stroke 2008; 39:29102917.
  • 23
    Reith J, Jorgensen HS, Pedersen PM et al. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996; 347:422425.
  • 24
    Castillo J, Davalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke [Research Support, Non-U.S. Gov't] 1998; 29:24552460.
  • 25
    den Hertog HM, van der Worp HB, van Gemert HM et al. The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol 2009; 8:434440.
  • 26
    Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346:557563.
  • 27
    Arrich J, Holzer M, Herkner H, Mullner M. Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2009; (4):CD004128.
  • 28
    Shankaran S, Laptook AR, Ehrenkranz RA et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353:15741584.
  • 29
    Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2007; (4):CD003311.
  • 30
    Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. Cochrane Database Syst Rev 2009; (2):CD001048.
  • 31
    Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev 2002; 39:5573.
  • 32
    Den Hertog HM, van der Worp HB, Tseng MC, Dippel DW. Cooling therapy for acute stroke. Cochrane Database Syst Rev 2009; (1):CD001247.
  • 33
    De Georgia MA, Krieger DW, Abou-Chebl A et al. Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 2004; 63:312317.
  • 34
    Guluma KZ, Hemmen TM, Olsen SE, Rapp KS, Lyden PD. A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology. Acad Emerg Med [Multicenter Study Randomized Controlled Trial] 2006; 13:820827.
  • 35
    Hemmen TM, Raman R, Guluma KZ et al. Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke 2010; 41:22652270.
  • 36
    Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 1992; 12:45654574.
  • 37
    Dottori M, Pera MF. Neuronal differenitation of human embryonic stem cells. Methods Mol Biol 2007; 438:1930.
  • 38
    Mitani A, Kataoka K. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience 1991; 42:661670.
  • 39
    Yue TL, Gu JL, Lysko PG, Cheng HY, Barone FC, Feuerstein G. Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons. Brain Res 1992; 574:193197.
  • 40
    Berger R, Jensen A, Hossmann KA, Paschen W. Effect of mild hypothermia during and after transient in vitro ischemia on metabolic disturbances in hippocampal slices at different stages of development. Brain Res Dev Brain Res 1998; 105:6777.
  • 41
    Onitsuka M, Mihara S, Inokuchi H, Shigemori M, Higashi H. Mild hypothermia protects rat hippocampal CA1 neurons from irreversible membrane dysfunction induced by experimental ischemia. Neurosci Res 1998; 30:16.
  • 42
    Popovic R, Liniger R, Bickler PE. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. Anesthesiology 2000; 92:13431349.
  • 43
    Garnier Y, Pfeiffer D, Jensen A, Berger R. Effects of mild hypothermia on metabolic disturbances in fetal hippocampal slices after oxygen/glucose deprivation depend on depth and time delay of cooling. J Soc Gynecol Investig 2001; 8:198205.
  • 44
    Xu L, Yenari MA, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab 2002; 22:2128.
  • 45
    Quinones-Hinojosa A, Malek JY, Ames A, 3rd, Ogilvy CS, Maynard KI. Metabolic effects of hypothermia and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the ischemic retina in vitro. Neurosurgery 2003; 52:11781186; discussion 86–7.
  • 46
    McManus T, Sadgrove M, Pringle AK, Chad JE, Sundstrom LE. Intraischaemic hypothermia reduces free radical production and protects against ischaemic insults in cultured hippocampal slices. J Neurochem 2004; 91:327336.
  • 47
    Yuan HB, Huang Y, Zheng S, Zuo Z. Hypothermic preconditioning increases survival of purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia. Anesthesiology 2004; 100:331337.
  • 48
    Feiner JR, Bickler PE, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA. Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg 2005; 100:215225.
  • 49
    Gisselsson LL, Matus A, Wieloch T. Actin redistribution underlies the sparing effect of mild hypothermia on dendritic spine morphology after in vitro ischemia. J Cereb Blood Flow Metab 2005; 25:13461355.
  • 50
    Rytter A, Cardoso CM, Johansson P et al. The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia. J Neurochem 2005; 95:11081117.
  • 51
    Lipski J, Park TI, Li D et al. Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Brain Res 2006; 1077:187199.
  • 52
    Liu RG, Wang WJ, Song N, Chen YQ, Li LH. Diazoxide preconditioning plus subsequent hypothermia increased resistance of rat cultured hippocampal neurons against hypoxia-reoxygenation injury. Chin Med J (Engl) 2006; 119:887893.
  • 53
    Yuan HB, Huang Y, Zheng S, Zuo Z. Hypothermic preconditioning reduces Purkinje cell death possibly by preventing the over-expression of inducibl nitric oxide synthase in rat cerebellar slices after an in vitro simulated ischemia. Neuroscience 2006; 142:381389.
  • 54
    Dalen ML, Froyland E, Saugstad OD, Mollnes TE, Rootwelt T. Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation. Brain Res 2009; 1259:8089.
  • 55
    Hua Y, Hisano K, Morimoto Y. Effect of mild and moderate hypothermia on hypoxic injury in nearly pure neuronal culture. J Anesth 2010; 26:6776.
  • 56
    Mitani A, Kadoya F, Kataoka K. Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices. Brain Res 1991; 562:159163.
  • 57
    Yuan HB, Huang YM, Zheng SQ, Zuo ZY. Hypothermic preconditioning increases survival of Purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia. Anesthesiology 2004; 100:331337.
  • 58
    Eberspacher E, Werner C, Engelhard K et al. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Acta Anaesthesiol Scand 2005; 49:477487.
  • 59
    Rootwelt T, Dunn M, Yudkoff M, Itoh T, Almaas R, Pleasure D. Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors. J Neurochem 1998; 71:15441553.
  • 60
    Pleasure SJ, Page C, Lee VM. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 1992; 12:18021815.
  • 61
    Schwartz CM, Spivak CE, Baker SC et al. NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells. Stem Cells and Development. 2005; 14:517534.
  • 62
    Woodruff TM, Thundyil J, Tang SC, Sobey CG, Taylor SM, Arumugam TV. Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener 2011; 6:11.
  • 63
    Axelrod YK, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin [Review] 2008; 26:585603, xi.
  • 64
    Hagerdal M, Harp J, Nilsson L, Siesjo BK. The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 1975; 24:311316.
  • 65
    Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in mammalian central nervous system. J Cereb Blood Flow Metab 2003; 23:513530.
  • 66
    Mowlavi A, Neumeister MW, Wilhelmi BJ, Song Y-H, Suchy H, Russell RC. Local hypothermia during early reperfusion protects skeletal muscle from ischemia-reperfusion injury. Plastic Reconstr Surg 2003; 111:242250.
  • 67
    Strbian D, Karjalainen-Lindsberg M-L, Kovanen PT, Tatlisumak T, Lindsberg PJ. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation 2007; 116:411418.
  • 68
    Aronowski J, Strong R, Grotta JC. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cerebral Blood Flow Metab 1997; 17:10481056.
  • 69
    Kallmunzer B, Schwab S, Kollmar R. Mild hypothermia of 34 degrees C reduces side effects of rt-PA treatment after thromboembolic stroke in rats. Exp Transl Stroke Med 2012; 4:3.
  • 70
    van der Worp HB, Macleod MR, Kollmar R. Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials[quest]. J Cereb Blood Flow Metab 2010; 30:10791093.
  • 71
    Yang XF, Ouyang Y, Kennedy BR, Rothman SM. Cooling blocks rat hippocampal neurotransmission by a presynaptic mechanism: observations using 2-photon microscopy. J Physiol 2005; 567(Pt 1):215224.
  • 72
    Schreckinger M, Marion DW. Contemporary management of traumatic intracranial hypertension: is there a role for therapeutic hypothermia? Neurocrit Care [Review] 2009; 11:427436.
  • 73
    Urbach A, Bar-Nur O, Daley GQ, Benvenisty N. Differential modeling of Fragile X syndrome by human embryonic stem cells and induced-pluripotent stem cells. Cell Stem Cell 2010; 6:407.
  • 74
    Feng Q, Lu SJ, Klimanskaya I et al. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Stem Cells 2010; 28:704712.
  • 75
    Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 1991; 75:1526.