• 1
    Leonardi-Bee J, Bath PMW, Phillips SJ, Sandercock PAG, for the IST Collaborative Group. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 2002; 33:13151320.
  • 2
    Willmot M, Leonardi-Bee J, Bath PM. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension 2004; 43:1824.
  • 3
    Sprigg N, Gray LJ, Bath PM et al. Relationship between outcome and baseline blood pressure and other haemodynamic measures in acute ischaemic stroke: data from the TAIST trial. J Hypertens 2006; 24:14131417.
  • 4
    Geeganage C, Tracy M, England T et al. Relationship between baseline blood pressure parameters (including mean pressure, pulse pressure, and variability) and early outcome after stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke 2011; 42:491493.
  • 5
    Sandset EC, Bath PM, Boysen G et al. The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled double-blind trial. Lancet 2011; 377:741750.
  • 6
    Anderson CS, Heeley E, Huang Y et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med 2013; 368:23552365.
  • 7
    Willmot MR, Bath PMW. The potential of nitric oxide therapeutics in stroke Expert Opinion Investigational. Drugs 2003; 12:455470.
  • 8
    Willmot M, Murphy S, Leonardi-Bee J, Bath P. Systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow. CerebrovascDis 2003; 16:S366 (abstract).
  • 9
    Butterworth RJ, Cluckie A, Jackson SHD, Buxton-Thomas M, Bath PMW. Pathophysiological assessment of nitric oxide (given as sodium nitroprusside) in acute ischaemic stroke. Cerebrovasc Dis 1998; 8:158165.
  • 10
    Bath PMW, Pathansali R, Iddenden R, Bath FJ. The effect of transdermal glyceryl trinitrate, anitric oxide donor, on blood pressure and platelet function in acute stroke. Cerebrovasc Dis 2001; 11:265272.
  • 11
    Rashid P, Weaver C, Leonardi-Bee JA, Fletcher S, Bath FJ, Bath PMW. The effects of transdermal glyceryl trinitrate, a nitric oxide donor on blood pressure, cerebral and cardiac haemodynamics and plasma nitric oxide levels in acute stroke. J Stroke Cerebrovasc Dis 2003; 13:143151.
  • 12
    Willmot M, Ghadami A, Whysall B, Clarke W, Wardlaw J, Bath PM. Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke. Hypertension 2006; 47:12091215.
  • 13
    Ankolekar SFM, Renton C, Cox P, Sprigg N, Siriwardena AN, Bath PM. Feasibility of an ambulance-based stroke trial and safety of glyceryl trinitrate in ultra acute stroke: the ‘Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial’ (RIGHT, ISRCTN66434824). Stroke 2013; 44:31203128.
  • 14
    Ankolekar S, Sare G, Geeganage C et al. Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in Patients with Ultra-Acute Stroke: study Protocol for the ‘Rapid Intervention with GTN in Hypertensive Stroke Trial’ (RIGHT, ISRCTN66434824). Stroke Res Treat 2012; 2012:385753. doi: 10.1155/2012/385753
  • 15
    The ENOS Trial Investigators. Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122). Int J Stroke 2006; 1:245249.
  • 16
    Wardlaw J, Bath P, Sandercock P et al. The NeuroGrid stroke examplar clinical trial protocol. Int J Stroke 2007; 2:6369.
  • 17
    Kobayashi A, Grabska K, Czlonkowska A, Gray LJ, Bath PMW. Efficacy of Nitric Oxide in Stroke – ENOS – a randomized trial – characteristics of patients recruited in Poland. Neurol Neurochir Pol 2008; 42:99104.
  • 18
    Sare GM, Gray LJ, Wardlaw J, Chen C, Bath PMW, Investigators FtET. Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke? Interim assessment in the ‘Efficacy of Nitric Oxide in Stroke’ Trial. Blood Press Monit 2009; 14:2025.
  • 19
    Ildiko SSS, Jurcau A, Simion A et al. The efficacy of nitric oxide in stroke (ENOS) Trial – where do we stand in Romania? Rom J Neurol 2012; XI:6874.
  • 20
    Ankolekar S, Renton C, Bereczki D et al. Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial. J Neurol Neurosurg Psychiatry 2012; 84:342347.
  • 21
    Whynes DK, Sprigg N, Selby J, Berge E, Bath PM. Testing for differential item functioning within the EQ-5D. Med Decis Making 2013; 33:252260.
  • 22
    De Silva DA, Omar E, Manzano JJ et al. Comparison of small volume infarcts of lacunar and non-lacunar etiologies. Int J Stroke 2013; 8:E2425.
  • 23
    Collins R, MacMahon S. Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials. Lancet 2001; 357:373380.
  • 24
    Lees KR, Bath PMW, Schellinger PD et al. Contemporary outcome measures in acute stroke research: choice of primary outcome measure. Stroke 2012; 43:11631170.
  • 25
    The Optimising Analysis of Stroke Trials (OAST) Collaboration. Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials. Stroke 2007; 38:19111915.
  • 26
    The Optimising Analysis of Stroke Trials (OAST) Collaboration. Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches. Int J Stroke 2008; 3:7884.
  • 27
    McHugh GS, Butcher I, Steyerberg EW et al. A simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project. Clin Trials 2010; 7:4457.
  • 28
    Sandercock P, Wardlaw JM, Lindley RI et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet 2012; 379:23522363.
  • 29
    The Optimising Analysis of Stroke Trials (OAST) Collaboration. Should stroke trials adjust functional outcome for baseline prognostic factors? Stroke 2009; 40:888894.
  • 30
    Weir CJ, Lees KR. Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial. StatMed 2003; 22:705726.
  • 31
    Bath PM, Lees KR, Schellinger PD et al. Statistical analysis of the primary outcome in acute stroke trials. Stroke 2012; 43:11711178.
  • 32
    Ali M, Bath PMB, Davis SM et al. The virtual international stroke trials archive (VISTA). Stroke 2007; 38:19051910.
  • 33
    Sandercock PA, Niewada M, Czlonkowska A. The International Stroke Trial database. Trials 2011; 12:101. doi: 10.1186/1745-6215-12-101