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References

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    Gleichmann U, Ingvar DH, Lubbers DW, Siesjo BK, Thews G. Tissue pO2 and pCO2 of the cerebral cortex, related to blood gas tensions. Acta Physiol Scand 1962; 55:127138.
  • 2
    Ponten U, Siesjo BK. Brain tissue carbon dioxide changes and cerebral blood flow measurements. Acta Neurol Scand Suppl 1965; 14:129134.
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    Ponten U, Siesjo BK. Acid-base relations in arterial blood and cerebrospinal fluid of the unanesthetized rat. Acta Physiol Scand 1967; 71:8995.
  • 4
    Eklof B, Siesjo BK. The effect of bilateral carotid artery ligation upon the blood flow and the energy state of the rat brain. Acta Physiol Scand 1972; 86:155165.
  • 5
    Lewis LD, Ponten U, Siesjo BK. Homeostatic regulation of brain energy metabolism in hypoxia. Acta Physiol Scand 1973; 88:284286.
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    Norberg K, Siesjo BK. Quantitative measurement of blood flow and oxygen consumption in the rat brain. Acta Physiol Scand 1974; 91:154164.
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    Davis JN, Carlsson A, MacMillan V, Siesjo BK. Brain tryptophan hydroxylation: dependence on arterial oxygen tension. Science 1973; 182:7274.
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    Carlsson C, Hagerdal M, Siesjo BK. Protective effect of hypothermia in cerebral oxygen deficiency caused by arterial hypoxia. Anesthesiology 1976; 44:2735.
  • 9
    Chapman AG, Meldrum BS, Siesjo BK. Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem 1977; 28:10251035.
  • 10
    Agardh CD, Kalimo H, Olsson Y, Siesjo BK. Hypoglycemic brain injury. I. Metabolic and light microscopic findings in rat cerebral cortex during profound insulin-induced hypoglycemia and in the recovery period following glucose administration. Acta Neuropathol 1980; 50:3141.
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    Berntman L, Dahlgren N, Siesjo BK. Cerebral blood flow and oxygen consumption in the rat brain during extreme hypercarbia. Anesthesiology 1979; 50:299305.
  • 12
    Gido G, Katsura K, Kristian T, Siesjo BK. Influence of plasma glucose concentration on rat brain extracellular calcium transients during spreading depression. J Cereb Blood Flow Metab 1993; 13:179182.
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    Siesjo BK, Berntman L. Cytoplasmic and mitochondrial redox changes in the brain during hypoxia. Adv Neurol 1979; 26:319323.
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    Siesjo BK, Rehncrona S, Smith D. Neuronal cell damage in the brain: possible involvement of oxidative mechanisms. Acta Physiol Scand Suppl 1980; 492:121128.
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    Siesjo BK. Brain Energy Metabolism. New York, John Wiley & Sons, 1978.
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    Rehncrona S, Rosen I, Siesjo BK. Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981; 1:297311.
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    Siesjo BK. Calcium and ischemic brain damage. Eur Neurol 1986; 25(Suppl 1):4556.
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    Siesjo BK, Agardh CD, Bengtsson F. Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1989; 1:165211.
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    Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia – the ischemic penumbra. Stroke 1981; 12:723725.
  • 20
    Siesjo BK. Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1981; 1:155185.
  • 21
    Zhao Q, Smith ML, Siesjo BK. The omega-conopeptide SNX-111, an N-type calcium channel blocker, dramatically ameliorates brain damage due to transient focal ischaemia. Acta Physiol Scand 1994; 150:459461.
  • 22
    Zhao Q, Pahlmark K, Smith ML, Siesjo BK. Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 1994; 152:349350.
  • 23
    Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjo BK. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1999; 19:778787.
  • 24
    Kuroda S, Janelidze S, Siesjo BK. The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. Brain Res 1999; 835:148153.
  • 25
    Memezawa H, Smith ML, Siesjo BK. Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 1992; 23:552559.
  • 26
    Kuroda S, Siesjo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 1997; 4:199212.
  • 27
    Siesjo BK, Siesjo P. Mechanisms of secondary brain injury. Eur J Anaesthesiol 1996; 13:247268.