• 1
    Gardiner D. The fate of the foreskin: a study of circumcision. BMJ 1947; 2: 14331437.
  • 2
    Oster J. Further fate of the foreskin. Incidence of preputial adhesions, phimosis, and smegma among Danish schoolboys. Arch. Dis. Child. 1968; 43: 200203.
  • 3
    Kayaba H, Tamura H, Kitajima S et al. Analysis of shape and retractability of the prepuce in 603 Japanese boys. J. Urol. 1996; 156: 18131815.
  • 4
    Imamura E. Phimosis of infants and young children in Japan. Acta Paediatr. Jpn. 1997; 39: 403405.
  • 5
    Glass JM. Religious circumcision: a Jewish view. BJU Int. 1999; 83 (Suppl.1): 1721.
  • 6
    Rizvi SAH, Naquvi SAA, Hussain M et al. Religious circumcision: a Muslim view. BJU Int. 1999; 83 (Suppl.1): 1316.
  • 7
    Ginsburg CM, McCracken GH Jr. Urinary tract infections in young infants. Pediatrics 1982; 69: 409412.
  • 8
    Wiswell TE, Smith FR, Bsaa JW. Decreased incidence of urinary tract infections in circumcised male infants. Pediatrics 1985; 75: 901903.
  • 9
    Wiswell TE, Roscelli JD. Corroborative evidence for the decresed incidence of urinary tract infections in circumcised male infants. Pediatrics 1986; 78: 9699.
  • 10
    Herzog LW. Urinary tract infections and circumcision. A case-control study. Am. J. Dis. Child. 1989; 143: 348350.
  • 11
    Wiswell TE, Hachey WE. Urinary tract infections and the circumcision state: an update. Clin. Pediatr. (Phila) 1993; 32: 130134.
  • 12
    Craig JC, Knight JF, Sureshkumar P et al. Effect of circumcision on incidence of urinary tract infection in preschool boys. J. Pediatr. 1996; 128: 2327.
  • 13
    To T, Agha M, Dick PT et al. Cohort study on circumcision of newborn boys and subsequent risk of urinary-tract infection. Lancet 1998; 352: 18131818.
  • 14
    Singh-Grewal D, Macdessi J, Craig J. Circumcision for the prevention of urinary tract infections in boys: a systematic review of randomized trials and observational studies. Arch. Dis. Child. 2005; 90: 853858.
  • 15
    Shaikh N, Morone NE, Bost JE et al. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr. Infect. Dis. J. 2008; 27: 302308.
  • 16
    Wijesinha SS, Atkins BL, Dudley NE et al. Does circumcision alter the periurethral bacterial flora? Pediatr. Surg. Int. 1998; 13: 146148.
  • 17
    Günşar C, Kurutepe S, Alparslan O et al. The effect of circumcision status on periurethral and glanular bacterial flora. Urol. Int. 2004; 72: 212215.
  • 18
    Tokgöz H, Polat F, Tan MÖ et al. Preputial bacterial colonization in preschool and primary school children. Int. Urol. Nephrol. 2005; 37: 101105.
  • 19
    Hallett RJ, Pead L, Maskell R. Urinary infection in boys a three year prospective study. Lancet 1976; 2: 11071110.
  • 20
    Glennon J, Ryan PI, Keane CT et al. Circumcision and periurethral carriage of Proteus mirabilis in boys. Arch. Dis. Child. 1988; 63: 556557.
  • 21
    Serour F, Samra Z, Kushel Z et al. Comparative periurethral bacteriology of uncircumcised and circumcised males. Genitourin. Med. 1997; 73: 288290.
  • 22
    Agartan CA, Kaya DA, Ozturk CE et al. Is aerobic preputial flora age dependent? Jpn. J. Infect. Dis. 2005; 58: 276278.
  • 23
    Herndon CDA, McKenna PH, Kolon TF et al. A multicenter outcomes analysis of patients with neonatal reflux presenting with prenatal hydronephrosis. J. Urol. 1999; 162: 12031208.
  • 24
    Kaneko K, Ohtomo Y, Shimizu T et al. Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatr. Nephrol. 2003; 18: 468470.
  • 25
    Cascio S, Colhoun E, Puri P. Bacterial colonization of the prepuce in boys with vesicoureteral reflux who receive antibiotic prophylaxis. J. Pediatr. 2001; 139: 160162.
  • 26
    Alsaywid BS, Saleh H, Deshpande A et al. High grade primary vesicoureteral reflux in boys: long-term results of a prospective cohort study. J. Urol. 2010; 184: 15981603.
  • 27
    Kwak C, Oh SJ, Lee A et al. Effect of circumcision on urinary tract infection after successful antireflux surgery. BJU Int. 2004; 94: 627629.
  • 28
    Mukherjee S, Joshi A, Carroll D et al. What is the effect of circumcision on risk of urinary tract infection in boys with posterior urethral valves? J. Pediatr. Surg. 2009; 44: 417421.
  • 29
    Auvert B, Taljaard D, Lagarde E et al. Randomized, controlled intervention trial of male Circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005; 2 (e298): 11121122.
  • 30
    Bailey RC, Moses S, Parker CB et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet 2007; 369: 643656.
  • 31
    Gray RH, Kigozi G, Serwadda D et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 2007; 369: 657666.
  • 32
    Buchbinder SP, Mehrotra DV, Duerr A et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008; 372: 18811893.
  • 33
    Sullivan PS, Kilmarx PH, Peterman TA et al. Male circumcision for prevention of HIV transmission: what the new data mean for HIV prevention in the United States. PLoS Med. 2007; 4: e223.
  • 34
    Moses S, Bailey RC, Ronald AR. Male circumcision: assessment of health benefits and risks. Sex. Transm. Infect. 1998; 74: 368373.
  • 35
    Patterson BK, Landy A, Siegel JN et al. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am. J. Pathol. 2002; 161: 867873.
  • 36
    McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS 2006; 20: 14911495.
  • 37
    Hussain LA, Lehner T. Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia. Immunology 1995; 85: 475484.
  • 38
    Fahrbach KM, Barry SM, Anderson MR et al. Enhanced cellular responses and environmental sampling within inner foreskin explants: implications for the foreskin's role in HIVtransmission. Mucosal Immunol. 2010; 3: 410418.
  • 39
    Price LB, Liu CM, Johnson KE et al. The effect of circumcision on the penis microbiome. PLos One 2010; 5: e8422.
  • 40
    Kogozi G, Wawer M, Ssettuba A et al. Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters). AIDS 2009; 23: 22092213.
  • 41
    O'Farrell N, Morison L, Moodley P et al. Association between HIV and subpreputial penile wetness in uncircumcised men in South Africa. J. Acquir. Immune Defic. Syndr. 2006; 43: 6977.
  • 42
    O'Farrell N, Morison L, Chung CK. Low prevalence of penile wetness among male sexually transmitted infection clinic attendees in London. Sex. Transm. Dis. 2007; 34: 408409.
  • 43
    Kapiga SH, Lyamuya EF, Lwihula GK et al. The incidence of HIV infection among women using family planning methods in Dar es Salaam, Tanzania. AIDS 1998; 12: 7584.
  • 44
    Gray RH, Kiwanuka N, Quinn TC et al. Male circumcision and HIV acquisition and transmission:cohort studies in Rakai, Uganda. Rakai Project Team. AIDS 2000; 14: 23712381.
  • 45
    Hunter DJ, Maggwa BN, Mati JK et al. Sexual behavior, sexually transmitted diseases, male circumcision and risk of HIV infection among women in Nairobi, Kenya. AIDS 1994; 8: 9399.
  • 46
    Malamba SS, Mermin JH, Bunnell R et al. Couples at risk: HIV-1 concordance and discordance among sexual partners receiving voluntary counseling and testing in Uganda. J. Acquir. Immune Defic. Syndr. 2005; 39: 576580.
  • 47
    Quinn TC, Wawer MJ, Sewankambo N et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N. Engl. J. Med. 2000; 342: 921929.
  • 48
    Chao A, Bulterys M, Musanganire F et al. Risk factors associated with prevalent HIV-1 infection among pregnant women in Rwanda. National University of Rwanda-Johns Hopkins University AIDS Research Team. Int. J. Epidemiol. 1994; 23: 371380.
  • 49
    Allen S, Lindan C, Serufilira A et al. Human immunodeficiency virus infection in urban Rwanda. Demographic and behavioral correlates in a representative sample of child bearing women. JAMA 1991; 266: 16571663.
  • 50
    Baeten JM, Donnell D, Kapiga SH et al. Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples. AIDS 2010; 24: 737744.
  • 51
    Buchbinder SP, Vittinghoff E, Heagerty PJ et al. Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States. J. Acquir. Immune Defic. Syndr. 2005; 39: 8289.
  • 52
    Kreiss JK, Hopkins SG. The association between circumcision status and human immunodeficiency virus infection among homosexual men. J. Infect. Dis. 1998; 168: 14041408.
  • 53
    Grulich AE, Hendry O, Clark E et al. Circumcision and male-to-male sexual transmission of HIV. AIDS 2001; 15: 11881189.
  • 54
    Templeton DJ, Jin F, Prestage GP et al. Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia. J. Infect. Dis. 2009; 200: 18131819.
  • 55
    Millett GA, Flores SA, Marks G et al. Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis. J. Am. Med. Assoc. 2008; 300: 16741684 [Erratum in: J Am Med Assoc 2009; 301: 1126–1129].
  • 56
    van Howe RS. Does circumcision influence sexually transmitted diseases?: a literature review. BJU Int. 1999; 83 (Suppl 1): 5262.
  • 57
    American Academy of Pediatrics. Circumcision policy statement. Task Force on Circumcision. Pediatrics 1999; 103: 686693.
  • 58
    Weiss HA, Thomas SL, Munabi SK et al. Male circumcision and risk of syphilis, chancroid and genital herpes: a systematic review and meta-analysis. Sex. Transm. Infect. 2006; 82: 101110.
  • 59
    van Howe RS. Genital ulcerative disease and sexually transmitted urethritis and circumcision: a metaanalysis. Int. J. STD AIDS 2007; 18: 799809.
  • 60
    Bwayo J, Plummer F, Omari M et al. Human immunodeficiency virus infection in long-distance truck drivers in east Africa. Arch. Intern. Med. 1994; 154: 13911396.
  • 61
    Cook LS, Koutsky LA, Holmes KK. Circumcision and sexually transmitted diseases. Am. J. Public Health 1994; 84: 197201.
  • 62
    Urassa M, Todd J, Boerma JT et al. Male circumcision and susceptibility to HIV infection among men in Tanzania. AIDS 1997; 11: 7380.
  • 63
    Tobian AAR, Serwadda D, Quinn TC et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N. Engl. J. Med. 2009; 360: 12981309.
  • 64
    Auvert B, Buvé A, Lagarde E et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS 2001; 15 (Suppl 4): S3140.
  • 65
    Weiss HA, Buve A, Robinson NJ et al. The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populations. AIDS 2001; 15 (Suppl 4): S97S108.
  • 66
    Xu F, Markowitz LE, Sternberg MR et al. Prevalence of circumcision and herpes simplex virus type 2 infection in men in the United States: the National Health and Nutrition Examination Survey (NHANES), 1999–2004. Sex. Transm. Dis. 2007; 34: 479484.
  • 67
    Reynolds SJ, Shepherd ME, Risbud AR et al. Male circumcision and risk of HIV-1 and other sexually transmitted infections in India. Lancet 2004; 363: 10391040.
  • 68
    Diseker RA, Peterman TA, Kamb ML et al. Circumcision and STD in the United States: cross sectional and cohort analyses. Sex. Transm. Infect. 2000; 76: 474479.
  • 69
    Sobngwi-Tambekou J, Taljaard D, Nieuwoudt M et al. Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis: observations in the aftermath of a randomised controlled trial for HIV prevention. Sex. Transm. Infect. 2009; 85: 116120.
  • 70
    Auvert B, Sobngwi-Tambekou J et al. Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: results of a randomized controlled trial conducted in orange farm, South Africa. J. Infect. Dis. 2009; 199: 1419.
  • 71
    Mehta SD, Moses S, Agot K et al. Adult male circumcision does not reduce the risk of incident Neisseria gonorrhoeae, Chlamydia trachomatis, or Trichomonas vaginalis Infection: results from a randomized, controlled trial in Kenya. J. Infect. Dis. 2009; 200: 370378.
  • 72
    Shabad AL. Some aspects of etiology and prevention of penile cancer. J. Urol. 1964; 92: 696702.
  • 73
    Schoen EJ. Neonatal circumcision and penile cancer. Evidence that circumcision is protective is overwhelming. BMJ 1996; 46: 313.
  • 74
    Daling JR, Madeleine MM, Johnson LG et al. Penile cancer: importance of circumcision, human pappilomavirus and smoking in in situ and invasive disease. Int. J. Cancer 2005; 116: 606616.
  • 75
    Dillner J, von Krogh G, Horenblas S et al. Etiology of squamous cell carcinoma of the penis. Scand. J. Urol. Nephrol. 2000; 205: 189193.
  • 76
    Paymaster JC, Gangadharan P. Cancer of the penis in India. J. Urol. 1967; 97: 110113.
  • 77
    Goel TC. Carcinoma penis. Q. Med. Rev. 1986; 37: 136.
  • 78
    Ekstrom T, Edsmyr F. Cancer of the penis: a clinical study of 229 cases. Acta Chir. Scand. 1958; 115: 2545.
  • 79
    Goel TC, Singh B. Carcinoma-penis in Muslims. Ind. Med. Gaz. 1977; 57: 202204.
  • 80
    Tseng H-F, Morgenstern H, Mack T et al. Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). Cancer Causes Control 2001; 12: 267277.
  • 81
    Larke NL, Thomas SL, dos Santos Silva I et al. Male circumcision and penile cancer: a systematic review and meta-analysis. Cancer Causes Control 2011; 22: 10971110.
  • 82
    Parkin DM, Bray F. Chapter 2: the burden of HPV-related cancers. Vaccine 2006; 24 (Suppl 3): S3/11325.
  • 83
    Frisch M, Friis S, Kjaer SK et al. Falling incidence of penis cancer in an uncircumcised population (Denmark 1943–90). BMJ 1995; 311: 1471.
  • 84
    de Sanjosé S, Diaz M, Castellsagué X et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect. Dis. 2007; 7: 453459.
  • 85
    Bergeron C, Barrasso R, Beaudenon S et al. Human papillomavirus associated with cervical intraepithelial neoplasia. Great diversity and distinct distribution in low- and high-grade lesions. Am. J. Surg. Pathol. 1992; 16: 641649.
  • 86
    Cupp MR, Malek RS, Goellner JR et al. The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J. Urol. 1995; 154: 10241029.
  • 87
    Castellsague X, Bosch FX, Munoz N et al. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N. Engl. J. Med. 2002; 346: 11051112.
  • 88
    Schiffman M, Castle PE, Jeronimo J et al. Human papillomavirus and cervical cancer. Lancet 2007; 370: 890907.
  • 89
    Muñoz N, Bosch FX, Castellsagué X et al. Against which human papillomavirus types shall we vaccinate and screen? The international perspective. Int. J. Cancer 2004; 111: 278285.
  • 90
    Veldhuijzen NJ, Snijders PJF, Reiss P et al. Factors affecting transmission of mucosal human papillomavirus. Lancet Infect. Dis. 2010; 10: 862874.
  • 91
    Parker SW, Stewart AJ, Wren MN et al. Circumcision and sexually transmissible diseases. Med. J. Aust. 1983; 2: 288290.
  • 92
    Donovan B, Basset I, Bodsworth NJ. Male circumcision and common sexually transmissible diseases in a developed nation setting. Genitourin. Med. 1994; 70: 317320.
  • 93
    Shin HR, Franceschi S, Vaccarella S et al. Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea. J. Infect. Dis. 2004; 190: 468476.
  • 94
    Weaver BA, Feng Q, Holmes KK et al. Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J. Infect. Dis. 2004; 189: 677685.
  • 95
    Madsen BS, van den Brule AJ, Jensen HL et al. Risk factors for squamous cell carcinoma of the penis – population-based case-control study in Denmark. Cancer Epidemiol. Biomarkers Prev. 2008; 17: 26832691.
  • 96
    Terris M, Wilson F, Nelson JH Jr. Relation of circumcision to cancer of the cervix. Am. J. Obstet. Gynecol. 1973; 117: 10561066.
  • 97
    Lu B, Wu Y, Nielson CM et al. Factors associated with acquisition and clearance of human papillomavirus infection in a cohort of US men: a prospective study. J. Infect. Dis. 2009; 199: 362371.
  • 98
    Brinton LA, Reeves WC, Brenes MM et al. The male factor in the etiology of cervical cancer among sexually monogamous women. Int. J. Cancer 1989; 44: 199203.
  • 99
    Wawer MJ, Tobian AA, Kigozi G et al. Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda. Lancet 2011; 377: 209218.