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Original Article
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Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes
Article first published online: 13 DEC 2012
DOI: 10.1111/imb.12005
© 2012 Royal Entomological Society
Additional Information
How to Cite
Totten, D. C., Vuong, M., Litvinova, O. V., Jinwal, U. K., Gulia-Nuss, M., Harrell, R. A. and Beneš, H. (2013), Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes. Insect Molecular Biology, 22: 18–30. doi: 10.1111/imb.12005
Publication History
- Issue published online: 18 JAN 2013
- Article first published online: 13 DEC 2012
Funded by
- National Institutes of Health, USA. Grant Number: AI046738
- College of Medicine Research Council
References
- , and (1992) A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Genes Dev 6: 466–480.
- , and (1993) A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119: 623–633.
- , , , , , et al. (2004) Formation and loss of large, unstable tandem arrays of the piggyBac transposable element in the yellow fever mosquito, Aedes aegypti. Transgenic Res 13: 411–425.
- , , and (2007) The role of larval fat cells in adult Drosophila melanogaster. J Exp Biol 210: 956–963.
- (2002) Re-engineering the sterile insect technique. Insect Biochem Mol Biol 32: 1243–1247.
- and (1995a) Integrating sex- and tissue-specific regulation within a single Drosophila enhancer. Genes Dev 9: 256–266.
- and (1995b) Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes. EMBO J 14: 1221–1230.
- , , and (1996) Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogaster. Mol Cell Biol 16: 3106–3111.
- , , , and (2009) The role of NF-kappaB factor REL2 in the Aedes aegypti immune response. Insect Biochem Mol Biol 39: 303–314.
- , , , , , et al. (2011) Comparative genomic analysis of Drosophila melanogaster and vector mosquito developmental genes. PLoS ONE 6: e21504.
- and (2008) Impact of technological improvements on traditional control strategies. Adv Exp Med Biol 627: 84–92.
- , , , , and (1996) Overlapping Lsp-2 gene sequences target expression to both the larval and adult Drosophila fat body. Insect Mol Biol 5: 39–49.
- , and (2010) microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A 107: 22391–22398.
- , , and (1998) The evolution of hexamerins and the phylogeny of insects. J Mol Evol 47: 93–108.
- (2002) Development. Doublesex in the middle. Science 297: 1135–1136.
- and (1989) Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56: 997–1010.
- , , and (2008) Comparative genomics of small RNA regulatory pathway components in vector mosquitoes. BMC Genomics 9: 425.
- , , , and (2001) Fat metabolism in insects. Annu Rev Nutr 21: 23–46.
- , and (2006) Densoviruses for control and genetic manipulation of mosquitoes. Adv Virus Res 68: 361–392.
- and (1993) The arthropod initiator: the capsite consensus plays an important role in transcription. Insect Biochem Mol Biol 23: 81–90.
- (1992) The Biology of Mosquitoes, 1st edn. Vol. 1. Chapman & Hall, New York.
- , , and (1998) Mariner transposition and transformation of the yellow fever mosquito, Aedes aegypti. Proc Natl Acad Sci U S A 95: 3748–3751.
- , , , , , et al. (2005) Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310: 667–670.
- , , , and (1997) Transient expression of the Drosophila melanogaster cinnabar gene rescues eye color in the white eye (WE) strain of Aedes aegypti. Insect Biochem Mol Biol 27: 993–997.
- and (1993) Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila. Genes Dev 7: 42–54.
- and (1997) Analysis of the mosquito lysosomal aspartic protease gene: an insect housekeeping gene with fat body-enhanced expression. Insect Biochem Mol Biol 27: 323–335.
- and (1992) Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers. Mol Cell Biol 12: 4093–4103.
- , and (1986) A tissue-specific transcription enhancer from the Drosophila yolk protein 1 gene. Cell 45: 859–867.
- , , , , , et al. (2009) Recent rapid rise of a permethrin knock down resistance allele in Aedes aegypti in Mexico. Plos Negl Trop Dis 3: e531.
- , and (2012) From cis-regulatory elements to complex RNPs and back. Cold Spring Harb Perspect Biol 4: a012245.
- and (1999) Germline transformation of Drosophila melanogaster with the piggyBac transposon vector. Insect Mol Biol 8: 449–457.
- (1996) Insect storage proteins: gene families and receptors. Insect Biochem Mol Biol 26: 755–765.
- and (2000) A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program. Proc Natl Acad Sci U S A 97: 8229–8232.
- and (2000) A versatile vector set for animal transgenesis. Dev Genes Evol 210: 630–637.
- , , , and (2002) Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite. Nature 417: 452–455.
- (2002) Engineering mosquito resistance to malaria parasites: the avian malaria model. Insect Biochem Mol Biol 32: 1317–1323.
- , , , , , et al. (1998) Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly. Proc Natl Acad Sci U S A 95: 3743–3747.
- , , , and (2006) Sex-, stage- and tissue-specific regulation by a mosquito hexamerin promoter. Insect Molec Biol 15: 301–311.
- , and (2011) Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res 90: 430–440.
- , , , , , et al. (1998) Three isoforms of a hepatocyte nuclear factor-4 transcription factor with tissue- and stage-specific expression in the adult mosquito. J Biol Chem 273: 29801–29810.
- and (2005) Developmental biology. Less steroids make bigger flies. Science 310: 630–631.
- , , , , and (2000) Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti. Proc Natl Acad Sci U S A 97: 9144–9149.
- , , , , and (2010) Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes. Proc Natl Acad Sci U S A 107: 8111–8116.
- , , and (1997a) Mosquito hexamerins: characterization during larval development. Insect Mol Biol 6: 11–21.
- , , and (1997b) Differential accumulation and tissue distribution of mosquito hexamerins during metamorphosis. Insect Biochem Mol Biol 27: 813–824.
- , , and (2008) Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. J Hered 99: 275–282.
- , , and (2009) Direct sequencing and expression analysis of a large number of miRNAs in Aedes aegypti and a multi-species survey of novel mosquito miRNAs. BMC Genomics 10: 581.
- , and (2010) Short GC-rich RNA similar to miR 1909 and 1915 folds in silico with the 5′-UTR and ORF of Notch and responders: potential for the elimination of cancer stem cells. Oncol Rep 24: 1443–1453.
- , , , , and (2009) Hormonal and nutritional regulation of insect fat body development and function. Arch Insect Biochem Physiol 71: 16–30.
- and (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25: 402–408.
- , and (2001) A novel GATA factor transcriptionally represses yolk protein precursor genes in the mosquito Aedes aegypti via interaction with the CtBP corepressor. Mol Cell Biol 21: 164–174.
- , , , , and (2010) Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito, Aedes aegypti. Insect Mol Biol 19: 753–763.
- and (2008) Cloning, characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi. BMC Genomics 9: 244.
- , , and (2012) Translational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection. BMC Genomics 13: 366.
- , and (2011) Translational control via protein-regulated upstream open reading frames. Cell 145: 902–913.
- , , , , , et al. (2011) Site-specific integration and expression of an anti-malarial gene in transgenic Anopheles gambiae significantly reduces Plasmodium infections. PLoS ONE 6: e14587.
- , and (2010) Mechanism of translational regulation by miR-2 from sites in the 5′ untranslated region or the open reading frame. RNA 16: 2493–2502.
- , and (1989) Genetic transformation of the mosquito Aedes aegypti by micro-injection of DNA. Med Vet Entomol 3: 1–7.
- and (1990) Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. Genes Dev 4: 89–97.
- , and (2006) Fat-body remodeling in Drosophila melanogaster. Genesis 44: 396–400.
- , , and (2006) High efficiency site-specific genetic engineering of the mosquito genome. Insect Mol Biol 15: 129–136.
- , , , , , et al. (2011) Developing transgenic Anopheles mosquitoes for the sterile insect technique. Genetica 139: 33–39.
- and (2008) Perspectives on the state of insect transgenics. Adv Exp Med Biol 627: 1–18.
- , , , , , et al. (2007) Late-acting dominant lethal genetic systems and mosquito control. BMC Biol 5: 1–11.
- , , and (2000) Green fluorescent protein as a genetic marker in transgenic Aedes aegypti. Insect Mol Biol 9: 1–10.
- (1994) D.melanogaster P element CaSpeR-hs43-lacZ gene transformation vector. GenBank/EMBL/DDBJ X81643.
- , , , and (2011) Malaria vector control: from past to future. Parasitol Res 108: 757–779.
- , , , , , et al. (2002) Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity. Insect Biochem Mol Biol 32: 1275–1286.
- , , , , , et al. (2008) Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes impacts Plasmodium gallinaceum development. Insect Mol Biol 17: 175–183.
- , , , , , et al. (2011) Genomic organization and splicing evolution of the doublesex gene, a Drosophila regulator of sexual differentiation, in the dengue and yellow fever mosquito Aedes aegypti. BMC Evol Biol 11: 41.
- , , and (2005) Identification of sex-specific transcripts of the Anopheles gambiae doublesex gene. J Exp Biol 208: 3701–3709.
- and (2012) Mosquito genomics: progress and challenges. Annu Rev Entomol 57: 143–166.
- and (1982) Juvenile hormone and the development of ovarian responsiveness to a brain hormone in the mosquito, Aedes aegypti. Gen Comp Endocrinol 46: 176–183.
- and (2010a) Doublesex: a conserved downstream gene controlled by diverse upstream regulators. J Genet 89: 341–356.
- and (2010b) Two female-specific DSX proteins are encoded by the sex-specific transcripts of dsx, and are required for female sexual differentiation in two wild silkmoth species, Antheraea assama and Antheraea mylitta (Lepidoptera, Saturniidae). Insect Biochem Mol Biol 40: 672–682.
- , , , and (2010) Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus. BMC Genomics 11: 119.
- , , , and (2003) Analysis of the biological functions of a doublesex homologue in Bombyx mori. Dev Genes Evol 213: 345–354.
- (2009) Egg formation in lepidoptera. J Insect Sci 9: 1–21.
- and (1991) The function and evolution of insect storage hexamers. Annu Rev Entomol 36: 205–228.
- and (2003) Storage hexamer utilization in Manduca sexta. J Insect Sci 3: 1–6.
- , , and (2000) Insect population control using a dominant, repressible, lethal genetic system. Science 287: 2474–2476.
- , , and (2007) Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion. Nucleic Acids Res 35: 6953–6962.
- , , , , , et al. (2011) Genetic elimination of dengue vector mosquitoes. Proc Natl Acad Sci U S A 108: 4772–4775.
- , , , , and (1997) Molecular cloning and expression of a hexamerin cDNA from the malaria mosquito, Anopheles gambiae. Eur J Biochem 246: 719–726.
- , , , , and (2001) Female-specific expression of a hexamerin gene in larvae of an autogenous mosquito. Eur J Biochem 268: 5713–5722.
- , and (2003) Posttranscriptional control of the competence factor betaFTZ-F1 by juvenile hormone in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A 100: 13338–13343.