These authors contributed equally to this work.
First screening of Aedes albopictus immunogenic salivary proteins
Article first published online: 29 MAY 2013
© 2013 Royal Entomological Society
Insect Molecular Biology
Volume 22, Issue 4, pages 411–423, August 2013
How to Cite
Doucoure, S., Cornelie, S., Patramool, S., Mouchet, F., Demettre, E., Seveno, M., Dehecq, J. S., Rutee, H., Herve, J. P., Favier, F., Missé, D., Gasque, P. and Remoue, F. (2013), First screening of Aedes albopictus immunogenic salivary proteins. Insect Molecular Biology, 22: 411–423. doi: 10.1111/imb.12032
- Issue published online: 2 JUL 2013
- Article first published online: 29 MAY 2013
- GIS CRVOI (Centre de Recherche et Veille en Océan Indien). Grant Number: PRAO/AIRD/CRVOI/08/01
- Institut de Recherche pour le Développement (IRD)
- Infectiopole Sud Foundation (Marseille, France)
- Ae. albopictus;
Study of the human antibody (Ab) response to Aedes salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus- and/or species-specific proteins is necessary to improve the accuracy of biomarkers. We analysed Aedes albopictus immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to Ae. albopictus or Ae. aegypti bites. Strong antigenicity to Ae. albopictus salivary proteins was detected in all individuals whatever the nature of Aedes exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of Ae. albopictus immunogenic salivary proteins for the first time.