These authors participated equally in this work.
Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding
Article first published online: 17 NOV 2013
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
Insect Molecular Biology
Volume 23, Issue 1, pages 122–131, February 2014
How to Cite
Arcà, B., Struchiner, C. J., Pham, V. M., Sferra, G., Lombardo, F., Pombi, M. and Ribeiro, J. M. C. (2014), Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding. Insect Molecular Biology, 23: 122–131. doi: 10.1111/imb.12068
- Issue published online: 1 JAN 2014
- Article first published online: 17 NOV 2013
- INFRAVEC project. Grant Number: 228421
- EVIMalaR NoE. Grant Number: 242095
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
- salivary glands
The saliva of bloodsucking animals contains dozens to hundreds of proteins that counteract their hosts’ haemostasis, inflammation and immunity. It was previously observed that salivary proteins involved in haematophagy are much more divergent in their primary sequence than those of housekeeping function, when comparisons were made between closely related organisms. While this pattern of evolution could result from relaxed selection or drift, it could alternatively be the result of positive selection driven by the intense pressure of the host immune system. We investigated the polymorphism of five different genes associated with blood-feeding in the mosquito Anopheles gambiae and obtained evidence in four genes for sites with signatures of positive selection. These results add salivary gland genes from bloodsucking arthropods to the small list of genes driven by positive selection.