• 1
    Centers for Disease Control and Prevention (CDC). Mortality among patients with tuberculosis and associations with HIV status — United States, 1993–2008. MMWR Morb Mortal Wkly Rep 2010; 59:150913.
  • 2
    Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol 2001; 19:93129.
  • 3
    Amigorena S, Webster P, Drake J, Newcomb J, Cresswell P, Mellman I. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J Exp Med 1995; 181:172941.
  • 4
    Rudensky AY, Maric M, Eastman S, Shoemaker L, DeRoos PC, Blum JS. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1994; 1:58594.
  • 5
    Tulp A, Verwoerd D, Dobberstein B, Ploegh HL, Pieters J. Isolation and characterization of the intracellular MHC class II compartment. Nature 1994; 369:1206.
  • 6
    Harding CV, Geuze HJ. Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment. J Immunol 1993; 151:398898.
  • 7
    Harding CV. Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules. Semin Immunol 1995; 7:35560.
  • 8
    Ramachandra L, Noss E, Boom WH, Harding CV. Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation. J Exp Med 2001; 194:142132.
  • 9
    Ramachandra L, Harding CV. Phagosomes acquire nascent and recycling class II MHC molecules but primarily use nascent molecules in phagocytic antigen processing. J Immunol 2000; 164:510312.
  • 10
    Ramachandra L, Simmons D, Harding CV. MHC molecules and microbial antigen processing in phagosomes. Curr Opin Immunol 2009; 21:98104.
  • 11
    Grotzke JE, Harriff MJ, Siler AC, Nolt D, Delepine J, Lewinsohn DA, Lewinsohn DM. The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog 2009; 5:113.
  • 12
    Torres M, Ramachandra L, Rojas RE, Bobadilla K, Thomas J, Canaday DH, Harding CV, Boom WH. Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages. Infect Immun 2006; 74:162130.
  • 13
    Inaba K, Turley S, Iyoda T et al. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med 2000; 191:92736.
  • 14
    Schaible UE, Sturgill-Koszycki S, Schlesinger PH, Russell DG. Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J Immunol 1998; 160:12906.
  • 15
    Jutras I, Houde M, Currier N et al. Modulation of the phagosome proteome by interferon-γ. Mol Cell Proteomics 2008; 7:697715.
  • 16
    Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P. The phagosomal proteome in interferon-γ-activated macrophages. Immunity 2009; 30:14354.
  • 17
    Via LE, Fratti RA, McFalone M, Pagan-Ramos E, Deretic D, Deretic V. Effects of cytokines on mycobacterial phagosome maturation. J Cell Sci 1998; 111(Pt 7):897905.
  • 18
    Koppelman B, Neefjes JJ, de Vries JE, de Waal Malefyt R. Interleukin-10 down-regulates MHC class II αβ peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling. Immunity 1997; 7:86171.
  • 19
    Tan JS, Canaday DH, Boom WH, Balaji KN, Schwander SK, Rich EA. Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis. J Immunol 1997; 159:2907.
  • 20
    Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T-cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. J Immunol Methods 2003; 281:12942.
  • 21
    Levi-Schaffer F, Riesel N, Soffer D, Abramsky O, Brenner T. Mast cell activity in experimental allergic encephalomyelitis. Mol Chem Neuropathol 1991; 15:17384.
  • 22
    Ramachandra L, Sramkoski RM, Canaday DH, Boom WH, Harding CV. Flow analysis of MHC molecules and other membrane proteins in isolated phagosomes. J Immunol Methods 1998; 213:5371.
  • 23
    Ramirez-Mata A, Michalak C, Mendoza-Hernandez G, Leon-Del-Rio A, Gonzalez-Noriega A. Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine β-glucuronidase. Exp Cell Res 2011; 317:236473.
  • 24
    Xie QW, Cho HJ, Calaycay J et al. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992; 256:2258.
  • 25
    MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997; 15:32350.
  • 26
    Casanova JL, Abel L. Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol 2002; 20:581620.
  • 27
    Filipe-Santos O, Bustamante J, Chapgier A et al. Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features. Semin Immunol 2006; 18:34761.
  • 28
    Lah TT, Hawley M, Rock KL, Goldberg AL. γ-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett 1995; 363:859.
  • 29
    Meissner M, Whiteside TL, Kaufmann R, Seliger B. CIITA versus IFN-γ induced MHC class II expression in head and neck cancer cells. Arch Dermatol Res 2009; 301:18993.
  • 30
    Clemens DL, Horwitz MA. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 1995; 181:25770.
  • 31
    Yates RM, Hermetter A, Taylor GA, Russell DG. Macrophage activation downregulates the degradative capacity of the phagosome. Traffic 2007; 8:24150.
  • 32
    Yates RM, Russell DG. Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome. Methods Mol Biol 2008; 445:31125.
  • 33
    de Beaucoudrey L, Samarina A, Bustamante J, Cobat A, Boisson-Dupuis S, Feinberg J. Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) 2010; 89:381402.
  • 34
    Jouanguy E, Doffinger R, Dupuis S, Pallier A, Altare F, Casanova JL. IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 1999; 11:34651.
  • 35
    Pedraza S, Lezana JL, Samarina A et al. Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor β1 deficiency. Pediatrics 2010; 126:e9716.
  • 36
    Happel KI, Lockhart EA, Mason CM, Porretta E, Keoshkerian E, Odden AR, Nelson S, Ramsay AJ. Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs. Infect Immun 2005; 73: 57828.
  • 37
    Thibodeau J, Bourgeois-Daigneault MC, Huppe G et al. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol 2008; 38:122530.
  • 38
    Redford PS, Murray PJ, O'Garra A. The role of IL-10 in immune regulation during M. tuberculosis infection. Mucosal Immunol 2011; 4:26170.
  • 39
    Torres MM-SP, Jimenez-Zamudio L, Teran L, Camarena A, Quezada R, Ramos E, Sada E. Comparison of the immune response against Mycobacterium tuberculosis antigens between a group of patients with active pulmonary tuberculosis and healthy household contacts. Clin Exp Immunol 1994; 96:758.
  • 40
    Torres M, Herrera T, Villareal H, Rich EA, Sada E. Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis. Infect Immun 1998; 66:17680.
  • 41
    Resende Co T, Hirsch CS, Toossi Z, Dietze R, Ribeiro-Rodrigues R. Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy. Clin Exp Immunol 2007; 147:4552.
  • 42
    Awomoyi AA, Marchant A, Howson JM, McAdam KP, Blackwell JM, Newport MJ. Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J Infect Dis 2002; 186:180814.