• 1
    Carroll HP, Paunovic V, Gadina M. Signalling, inflammation and arthritis: crossed signals: the role of interleukin-15 and -18 in autoimmunity. Rheumatology (Oxford) 2008; 47:126977.
  • 2
    Dubois S, Magrangeas F, Lehours P et al. Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA results in a shortened form with a distinct pattern of expression. J Biol Chem 1999; 274:2697884.
  • 3
    Mortier E, Bernard J, Plet A, Jacques Y. Natural, proteolytic release of a soluble form of human IL-15 receptor α-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 2004; 173:16818.
  • 4
    Anderson DM, Kumaki S, Ahdieh M et al. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15RA and IL2RA genes. J Biol Chem 1995; 270:298629.
  • 5
    Ruckert R, Brandt K, Braun A et al. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J Immunol 2005; 174:550715.
  • 6
    Rubinstein MP, Kovar M, Purton JF, Cho JH, Boyman O, Surh CD, Sprent J. Converting IL-15 to a superagonist by binding to soluble IL-15Rα. Proc Natl Acad Sci U S A 2006; 103:916671.
  • 7
    Stonier SW, Schluns KS. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett 2010; 127:8592.
  • 8
    Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR. Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev 2010; 22:1933.
  • 9
    Nishiwaki T, Ina K, Goto H et al. Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease. J Gastroenterol 2005; 40:12836.
  • 10
    Liu Z, Geboes K, Colpaert S, D'Haens GR, Rutgeerts P, Ceuppens JL. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J Immunol 2000; 164:360815.
  • 11
    Bouchaud G, Mortier E, Flamant M, Barbieux I, Plet A, Galmiche JP, Jacques Y, Bourreille A. Interleukin-15 and its soluble receptor mediate the response to infliximab in patients with Crohn's disease. Gastroenterology 2010; 138:237887.
  • 12
    Arijs I, De Hertogh G, Lemaire K et al. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS ONE 2009; 4:e7984.
  • 13
    Arijs I, De Hertogh G, Machiels K et al. Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment. Am J Gastroenterol 2011; 106:74861.
  • 14
    Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45.
  • 15
    Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y. Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J Immunol 1998; 160:93642.
  • 16
    Yoshihara K, Yajima T, Kubo C, Yoshikai Y. Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice. Gut 2006; 55:33441.
  • 17
    Blaydon DC, Biancheri P, Di WL et al. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med 2011; 365:15028.
  • 18
    Dubois S, Mariner J, Waldmann TA, Tagaya Y. IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 2002; 17:53747.
  • 19
    Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002; 298:2199202.
  • 20
    Tengvall S, Lundgren A, Quiding-Jarbrink M, Svennerholm AM. BAFF, stimulatory DNA and IL-15 stimulates IgA+ memory B cells and provides a novel approach for analysis of memory responses to mucosal vaccines. Vaccine 2010; 28:544550.
  • 21
    Epron G, Ame-Thomas P, Le Priol J, Pangault C, Dulong J, Lamy T, Fest T, Tarte K. Monocytes and T cells cooperate to favor normal and follicular lymphoma B-cell growth: role of IL-15 and CD40L signaling. Leukemia 2012; 26:13948.
  • 22
    Esen M, Forster J, Ajua A, Spankuch I, Paparoupa M, Mordmuller B, Kremsner PG. Effect of IL-15 on IgG versus IgE antibody-secreting cells in vitro. J Immunol Methods 2012; 2:713.
  • 23
    Jourdan M, Caraux A, Caron G et al. Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation. J Immunol 2011; 187:393141.
  • 24
    Jourdan M, Caraux A, De Vos J et al. An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization. Blood 2009; 114:517381.
  • 25
    Schneider R, Mohebiany AN, Ifergan I, Beauseigle D, Duquette P, Prat A, Arbour N. B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. J Immunol 2011; 187:411928.
  • 26
    Schulthess J, Meresse B, Ramiro-Puig E et al. Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes. Immunity 2012; 37:10821.