The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis

Authors

  • Flor M. Perez-Campo,

    1. Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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  • Guilherme Costa,

    1. Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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  • Michael Lie-a-Ling,

    1. Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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  • Valerie Kouskoff,

    1. Cancer Research UK Stem Cell Haematopoiesis Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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  • Georges Lacaud

    Corresponding author
    • Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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Correspondence: Georges Lacaud, Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road, M20 4BX, Manchester, UK. Email: glacaud@picr.man.ac.uk Flor M. Perez-Campo, Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road,M20 4BX, Manchester, UK. Email: fperezcampo@picr.man.ac.uk

Senior author: Dr Georges Lacaud

Summary

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A1) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

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