• 1
    Parviainen S, Taivainen A, Liukko A, Nieminen A, Rytkonen-Nissinen M, Kinnunen T, Virtanen T. Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1. J Allergy Clin Immunol 2010; 136:137787.
  • 2
    Kinnunen T, Nieminen A, Kwok WW, Narvanen A, Rytkonen-Nissinen M, Saarelainen S, Taivainen A, Virtanen T. Allergen-specific naive and memory CD4+ T cells exhibit functional and phenotypic differences between individuals with or without allergy. Eur J Immunol 2010; 40:24609.
  • 3
    Bateman EA, Ardern-Jones MR, Ogg GS. Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+ T cells. J Allergy Clin Immunol 2006; 118:13506.
  • 4
    Delong JH, Hetherington Simpson K, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1-reactive T cells in individuals with peanut allergy. J Allergy Clin Immunol 2011; 127:12118.
  • 5
    Macaubas C, Wahlstrom J, Galvao da Silva AP, Forsthuber TG, Sonderstrup G, Kwok WW, DeKruyff RH, Umetsu DT. Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals. J Immunol 2006; 176:506977.
  • 6
    Wambre E, Delong JH, James EA, Lafond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol 2012; 129:54451.
  • 7
    Kwok WW, Roti M, Delong JH, Tan V, Wambre E, James EA, Robinson D. Direct ex vivo analysis of allergen-specific CD4+ T cells. J Allergy Clin Immunol 2010; 125:14079.
  • 8
    Virtanen T, Kinnunen T. Mammalian allergens. J Allergy Clin Immunol 2008; 21:20118.
  • 9
    Dandeu JP, Rabillon J, Divanovic A, Carmi-Leroy A, David B. Hydrophobic interaction chromatography for isolation and purification of, the horse major allergen. J Chromatogr 1993; 621:2331.
  • 10
    Saarelainen S, Rytkonen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. Clin Exp Allergy 2008; 38:37481.
  • 11
    Immonen A, Kinnunen T, Sirven P et al. The major horse allergen Equ c 1 contains one immunodominant region of T cell epitopes. Clin Exp Allergy 2007; 37:93947.
  • 12
    Kauppinen A, Perasaari J, Taivainen A et al. Association of HLA class II alleles with sensitization to cow dander Bos d 2, an important occupational allergen. Immunobiology 2012; 217:812.
  • 13
    Hermann R, Turpeinen H, Laine AP et al. HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in finland: an analysis of 622 nuclear families. Tissue Antigens 2003; 62:1629.
  • 14
    Juntunen R, Liukko A, Taivainen A et al. Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells. Mol Immunol 2009; 46:33207.
  • 15
    Kinnunen T, Taivainen A, Partanen J, Immonen A, Saarelainen S, Rytkonen-Nissinen M, Rautiainen J, Virtanen T. The DR4-DQ8 haplotype and a specific T cell receptor vbeta T cell subset are associated with absence of allergy to Can f 1. Clin Exp Allergy 2005; 35:797803.
  • 16
    Novak EJ, Liu AW, Nepom GT, Kwok WW. MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen. J Clin Invest 1999; 104:637.
  • 17
    Zeiler T, Mantyjarvi R, Rautiainen J, Rytkonen-Nissinen M, Vilja P, Taivainen A, Kauppinen J, Virtanen T. T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule. J Immunol 1999; 162:141522.
  • 18
    Oseroff C, Sidney J, Kotturi MF et al. Molecular determinants of T cell epitope recognition to the common timothy grass allergen. J Immunol 2010; 185:94355.
  • 19
    Van Overtvelt L, Wambre E, Maillere B et al. Assessment of Bet v 1-specific CD4+ T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers. J Immunol 2008; 180:451422.
  • 20
    Wambre E, James EA, Kwok WW. Characterization of CD4+ T cell subsets in allergy. Curr Opin Immunol 2012; 24:7006.
  • 21
    Pala P, Message SD, Johnston SL, Openshaw PJ. Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults. Clin Exp Allergy 2002; 32:173944.
  • 22
    Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr VA, Robinson DS. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004; 363:60815.
  • 23
    Skrindo I, Farkas L, Kvale EO, Johansen FE, Jahnsen FL. Depletion of CD4+CD25+CD127lo regulatory T cells does not increase allergen-driven T cell activation. Clin Exp Allergy 2008; 38:17529.
  • 24
    Walker SM, Durham SR, Till SJ et al. Immunotherapy for allergic rhinitis. Clin Exp Allergy 2011; 41:1177200.
  • 25
    Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Vina M. New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 2003; 62:296307.
  • 26
    Jahn-Schmid B, Wopfner N, Hubinger G, Asero R, Ebner C, Ferreira F, Bohle B. The T-cell response to amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements. J Allergy Clin Immunol 2010; 126:106871.