Emerging role of interleukin-33 in autoimmune diseases

Authors

  • Cheng Pei,

    1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    2. Department of Ophthalmology, First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, Xi'an, China
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  • Mark Barbour,

    1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
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  • Karen J. Fairlie-Clarke,

    1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
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  • Debbie Allan,

    1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
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  • Rong Mu,

    Corresponding author
    1. Institute of Rheumatology and Immunology, People's Hospital, Peking University, Beijing, China
    • Correspondence: H.-R. Jiang, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK. Email: huirong.jiang@strath.ac.uk

      or

      R. Mu, Institute of Rheumatology and Immunology, People's Hospital, Peking University, Beijing, China. Email: murongser@gmail.com

      Senior author: Hui-Rong Jiang

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  • Hui-Rong Jiang

    Corresponding author
    1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    • Correspondence: H.-R. Jiang, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK. Email: huirong.jiang@strath.ac.uk

      or

      R. Mu, Institute of Rheumatology and Immunology, People's Hospital, Peking University, Beijing, China. Email: murongser@gmail.com

      Senior author: Hui-Rong Jiang

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Summary

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

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