Lack of transglutaminase 2 diminished T-cell responses in mice
Article first published online: 10 JUN 2014
© 2014 John Wiley & Sons Ltd
Volume 142, Issue 3, pages 506–516, July 2014
How to Cite
Kim, J.-H., Hong, J. M., Jeong, E. M., Lee, W. J., Kim, H.-R., Kang, J. S., Kim, I.-G. and Hwang, Y.-i. (2014), Lack of transglutaminase 2 diminished T-cell responses in mice. Immunology, 142: 506–516. doi: 10.1111/imm.12282
- Issue published online: 10 JUN 2014
- Article first published online: 10 JUN 2014
- Accepted manuscript online: 15 MAR 2014 03:19AM EST
- Manuscript Accepted: 11 MAR 2014
- Manuscript Revised: 8 MAR 2014
- Manuscript Received: 18 DEC 2013
- National Research Foundation of Korea (NRF)
- Korean Government. Grant Number: 2010-0010184
Figure S1. Fractions of CD4+ and CD8+ subsets in the spleen.
Figure S2. In vitro proliferation of wild-type (WT) and transglutaminase 2 deficient (TG2−/−) T cells. Splenic T cells were isolated, loaded with CFSE, and stimulated with anti-CD3 and anti-CD28 antibodies for 6 days.
Figure S3. Naive T cells from un-immunized mice were isolated, stained for CD8, CD44, CD62L and CD127 without stimulation, gated on CD8, and subjected to flow cytometric analysis.
Figure S4. Comparison of the dead cell frequencies between wild-type (WT) and transglutaminase 2 deficient (TG2−/−) T cells after 3-day in vitro activation with anti-CD3 and anti-CD28 antibodies, as shown in Fig. 3.
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