‘As above, so below’ examining the interplay between emotion and the immune system

Authors

  • Samuel Brod,

    1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Search for more papers by this author
  • Lorenza Rattazzi,

    1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Search for more papers by this author
  • Giuseppa Piras,

    1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Search for more papers by this author
  • Fulvio D'Acquisto

    Corresponding author
    1. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    • Correspondence: F. D'Acquisto, The William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK.

      Email: F.Dacquisto@qmul.ac.uk

      Senior author: Fulvio D'Acquisto and Samuel Brod, e-mail: s.brod@qmul.ac.uk

    Search for more papers by this author

Summary

While the concept of a palpable relationship between our mental and physical well-being is certainly not new, it is only in the light of modern scientific research that we have begun to realize how deeply connected our emotional and immune states may be. We begin this review with a series of studies demonstrating how four fundamental emotional responses: anger, anxiety, mirth and relaxation are able modulate cytokine production and cellular responses to a variety of immune stimuli. These modulations are shown to be either detrimental or beneficial to a patient's health dependent on the context and duration of the emotion. We also discuss the reverse, highlighting research demonstrating how the loss of key immune cells such as T lymphocytes in clinical and animal studies can negatively impact both emotional well-being and cognition. Additionally, to give a more complete picture of the manifold pathways that link emotion and the immune system, we give a brief overview of the influence the digestive system has upon mental and immunological health. Finally, throughout this review we attempt to highlight the therapeutic potential of this burgeoning field of research in both the diagnosis and treatment of immune and disorders. As well as identifying some of the key obstacles the field must address in order to put this potential into practice.

Ancillary