MicroRNA regulation of T-cell differentiation and function

Authors

  • Lukas T. Jeker,

    1. Diabetes Center, University of California San Francisco, San Francisco, CA, USA
    2. Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA
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    • Lukas T. Jeker's ORCID ID: 0000-0002-3359-8796

  • Jeffrey A. Bluestone

    1. Diabetes Center, University of California San Francisco, San Francisco, CA, USA
    2. Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA
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Correspondence to:

Jeffrey A. Bluestone

University of California, San Francisco, S-115 Box 0400

513 Parnassus Ave

San Francisco, CA 94143, USA

Tel.: +1 415 476 4451

Fax: +1 415 476 0816

e-mail: jeff.bluestone@ucsf.edu

Summary

MicroRNAs (miRNAs) are emerging as key controllers of T-cell differentiation and function. Their expression is dynamically regulated by extracellular signals such as costimulation and cytokine signals. miRNAs set thresholds for gene expression and optimize protein concentrations of genetic networks. Absence of individual miRNAs can lead to severe immune dysfunction. In this study, we review emerging principles and provide examples of important functions exerted by miRNAs. Although our understanding of miRNA function in T-cell differentiation is still rudimentary, the available evidence leaves no doubt that these small post-transcriptional regulators are indispensable for proper functioning of the immune system.

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