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Appendix S1. Search strategy in electronic databases.

Appendix S2. Tool for assessing susceptibility to bias in observational studies.

Appendix S3. Country-wise reports on national health situations on influenza and ARI.

Appendix S4. Prevalence of influenza by country and year.

Appendix S5. Yearly ILI activity report1999–2008 by country in LA&C# (FLUNET reports).

Map S1. Prevalence and Type/Subtype distribution 1999.

Map S2. Prevalence and Type/Subtype distribution 2000.

Map S3. Prevalence and Type/Subtype distribution 2001.

Map S4. Prevalence and Type/Subtype distribution 2002.

Map S5. Prevalence and Type/Subtype distribution 2003.

Map S6. Prevalence and Type/Subtype distribution 2004.

Map S7. Prevalence and Type/Subtype distribution 2005.

Map S8. Prevalence and Type/Subtype distribution 2006.

Map S9. Prevalence and Type/Subtype distribution 2007.

Map S10. Prevalence and Type/Subtype distribution 2008.

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