Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China

Authors

  • Guohong Huang,

    1. Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China
    2. Xinjiang Medical University, Urumqi, China
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    • These authors contributed equally to this study.
  • Deshan Yu,

    1. Gansu Center for Disease Control and Prevention, Lanzhou, China
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    • These authors contributed equally to this study.
  • Zhen Zhu,

    1. Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China
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  • Hai Zhao,

    1. Gansu Center for Disease Control and Prevention, Lanzhou, China
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  • Peng Wang,

    1. Gansu Center for Disease Control and Prevention, Lanzhou, China
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  • Gregory C. Gray,

    1. Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA
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  • Lei Meng,

    Corresponding author
    1. Gansu Center for Disease Control and Prevention, Lanzhou, China
    • Correspondence: Wenbo Xu, Chief of National Lab for Measles, Acting Chief of National Lab for Poliomyelitis, Institute of Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai road 155, Changping Qu, Beijing 102206, China. E-mail: wenbo_xu1@yahoo.com.cn and Lei Meng, PhD, Gansu Center for Disease and Prevention, No. 230, Dong Gang West Road, Lanzhou 730000, China.

      E-mail: ccdcusc101@163.com

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  • Wenbo Xu

    Corresponding author
    1. Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China
    • Correspondence: Wenbo Xu, Chief of National Lab for Measles, Acting Chief of National Lab for Poliomyelitis, Institute of Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai road 155, Changping Qu, Beijing 102206, China. E-mail: wenbo_xu1@yahoo.com.cn and Lei Meng, PhD, Gansu Center for Disease and Prevention, No. 230, Dong Gang West Road, Lanzhou 730000, China.

      E-mail: ccdcusc101@163.com

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Abstract

Objectives

Human adenovirus (HAdV) type 14 had been infrequently associated with outbreaks of febrile respiratory illness (FRI) until the HAdV-14p1 emerged in 2006 and rapidly spread in the United States. Here, we report an outbreak of FRI caused by HadV-14p1 that occurred in 2011 at a primary and middle school in China.

Design

The basic information of the outbreak was recored; throat swabs were collected from 17 patients, polymerase chain reaction, A549 cell culture, and sequencing were used to identify the pathogen of the outbreak..

Results

Total of 43 students were infected in this outbreak. Boys were more than girls. We identified 11 HAdV-positive specimens and 6 HAdV isolates. Genetic analysis showed that the complete hexon, fiber, and E1A sequences of isolates were nearly 100% identical with other HAdV-14p1 sequences deposited in GenBank.

Conclusions

HadV-14p1 has caused outbreaks of pneumonia and mortality among adults in the United States and Europe. It may cause similar conditions among Chinese adults due to poor hygiene and sanitation. It seems prudent for China to develop a national surveillance system to determine the etiology of severe respiratory diseases and deaths among adults and school-aged children.

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