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Data S1. Mortality Data.

Table S1. Adjustment ratio of specimens positive for influenza using virus culture to assay of polymerase chain reaction (PCR).

Table S2. Annual deaths rates (per 100 000 people) by cause of death, region, and season, 2004-05 through 2009-10.

Table S3. Influenza-associated excess death rates (per 100,000 people) due to all-cause for Northern and Sothern Disease Surveillance Point sites.

Table S4. Influenza-associated excess death rates (per 100,000 people) due to respiratory diseases for Northern and Sothern Disease Surveillance Point sites.

Table S5. Coefficients of negative binomial regression models used to derived excess mortality estimates, by age and region.

Table S6. Comparison of influenza-associated excess death rates (per 100 000 people) due to respiratory and circulatory diseases by negative binomial (NB) models and Serfling models.

Table S7. Influenza-associated excess death rates (per 100,000 people) due to respiratory diseases in persons ≥65 years old by negative binomial models with different lags between virological data and respiratory death outcomes.

Figure S1. Weekly number of specimens tested and percentage of influenza positive in Northern and Southern China.

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