Respiratory virus infections in hospitalized children and adults in Lao PDR
Article first published online: 25 JUN 2013
© 2013 John Wiley & Sons Ltd
Influenza and Other Respiratory Viruses
Volume 7, Issue 6, pages 1070–1078, November 2013
How to Cite
2013) Respiratory virus infections in hospitalized children and adults in Lao PDR. Influenza and Other Respiratory Viruses 7(6), 1070–1078.et al. (
- Issue published online: 5 NOV 2013
- Article first published online: 25 JUN 2013
- Manuscript Accepted: 14 MAY 2013
- Surveillance and Investigation of Epidemic Situations in South-East Asia (SISEA)
- French Agency for Development (AFD)
- Acute lower respiratory infection;
- Lao People's Democratic Republic;
- respiratory viruses;
- South-East Asia
Acute respiratory infections are an important cause of morbidity and mortality worldwide, with a major burden of disease in developing countries. The relative contribution of viruses in acute lower respiratory infections (ALRI) is, however, poorly documented in Lao PDR.
The objective of this study is to investigate the etiology of ALRI in patients of all ages in two hospitals of Laos.
Multiplex PCR/RT-PCR methods were used to target 18 major common respiratory viruses. Between August 2009 and October 2010, samples from 292 patients presenting with ALRI were collected.
Results and conclusion
Viruses were detected in 162 (55%) samples. In 48% (140/292) of the total ALRI cases, a single virus was detected while coinfections were observed in 8% (22/292) of the samples. The most frequent viruses were rhinovirus/enterovirus (35%), human respiratory syncytial virus (26%), and influenza viruses (13%). Parainfluenza viruses were detected in 9%, adenovirus in 6%, human metapneumovirus in 4%, coronaviruses (229E, NL63, OC43, HKU1) in 4%, and bocavirus in 3% of ALRI specimens. Most viral infections occurred in patients below 5 years of age. The distribution of viruses varied according to age-groups. No significant correlation was observed between the severity of the disease and the age of patients or the virus species. This study provides the description of viral etiology among patients presenting with ALRI in Lao PDR. Additional investigations are required to better understand the clinical role of the different viruses and their seasonality in Laos.