Swine influenza: clinical, serological, pathological, and virological cross-sectional studies in nine farms in Argentina
Article first published online: 14 NOV 2013
© 2013 Blackwell Publishing Ltd
Influenza and Other Respiratory Viruses
Special Issue: Proceedings of the 2nd International Symposium on Neglected Influenza Viruses, Dublin, Ireland, 7-8 March 2013. Edited by: Thomas Chambers and Ariel Pereda. Publication of this supplement was supported by isirv.
Volume 7, Issue Supplement s4, pages 10–15, December 2013
How to Cite
2013) Swine influenza: clinical, serological, pathological, and virological cross-sectional studies in nine farms in Argentina. Influenza and Other Respiratory Viruses 7 (Suppl. 4), 10–15.et al. (
- Issue published online: 14 NOV 2013
- Article first published online: 14 NOV 2013
- Center for Research on Influenza Pathogenesis (CRIP)
- Proyecto Específico INTA Exóticas y Emergentes. Grant Number: AESA201731
- European Community (Proyecto Integrado Cadena Carne Aviar – BiotecSur
- Ministerio de Ciencia
- Tecnología e Innovación Productiva from Argentina
- Secretaría de Ciencia y Técnica
- Universidad Nacional de La Plata (Argentina)
Influenza A viruses (IAV) are important pathogens responsible for economic losses in the swine industry and represent a threat to public health. In Argentina, clinical, pathological, and virological findings suggest that IAV infection is widespread among pig farms. In addition, several subtypes of IAV, such as pH1N1, H3N2, δ1H1N1, and δ2H1N2, have been reported.
To evaluate the infection patterns of influenza virus in nine pig farms in Argentina.
Clinical, serological, pathological, and virological cross-sectional studies were conducted.
Clinical and pathological results were characteristic of endemic influenza infection in eight of the nine farms studied. By rRT-PCR, six of the nine farms were positive to influenza. Five IAV were obtained. Genome analysis determined that four of the isolations were pH1N1 and that the remaining one was a reassortant human origin H3N2 virus containing pandemic internal genes. Serological results showed that all farms were positive to influenza A antibodies. Moreover, the hemagglutination inhibition test showed that infection with viruses containing HA′s from different subtypes (pH1, δ1H1, δ2H1, and H3) is present among the farms studied and that coinfections with two or more subtypes were present in 80.5% of positive pigs.
Because vaccines against IAV are not licensed in Argentina, these results reflect the situation of IAV infection in non-vaccinated herds. This study provides more information about the circulation and characteristics of IAV in a poorly surveyed region. This study provides more data that will be used to evaluate the tools necessary to control this disease.